[摘要]目的：探讨口服小剂量异维A酸联合外用2%超分子水杨酸治疗中重度痤疮的临床疗效。方法：共选取74例中重度痤疮患者作为研究对象，口服小剂量异维A酸10mg，1次/d。治疗组：37例，联合外用2%新型超分子水杨酸治疗;对照组：37例，联合外用夫西地酸乳膏及阿达帕林凝胶治疗。对两组患者治疗前后的皮损数量变化及治疗效果进行对比分析。结果：经过8周的治疗，两组研究对象的总皮损数量较治疗前均显著减少(P<0.05)，且治疗组与对照组比较，无明显差异(P>0.05)。针对不同类型的皮损，治疗组对粉刺的疗效比对照组更具优势，对丘疹与结节的疗效无明显差异。结论：治疗中重度痤疮，小剂量异维A酸联合外用2%超分子水杨酸临床疗效较好，副作用小，可作为痤疮治疗的新选择。

    [关键词]异维A酸;小剂量;超分子水杨酸;中重度痤疮;有效率

    [中图分类号]R758.73+3 [文献标志码]A [文章编号]1008-6455(2020)05-0016-04

    Abstract： Objective Toobserve the clinical efficacy of oral low-dose isotretinoin combined with 2% supramolecular salicylic acid in the treatment of moderate and severe acne. Methods A total of 74 patients with moderate to severe acne were included and treated with low-dose isotretinoin(10mg) daily. The treatment group was treated combined with 2% supramolecular salicylic acid ......