唐小清 魏红

    [摘要]目的：观察重组人表皮生长因子(rhEGF)联合舒宁乳膏对黄褐斑皮损及皮肤屏障修复的作用。方法：选择笔者医院治疗的34例黄褐斑伴皮肤屏障受损患者，每日使用重组人表皮生长因子及舒宁乳膏2次，早晚各一次，分别在治疗前、治疗1个月、2个月后采用VISIA皮肤检测仪对皮肤状态进行检测，并对患者进行自我满意度调查。结果：连续使用重组人表皮生长因子及舒宁乳膏2个月后，VISIA皮肤测试结果表明与治疗前比较皮肤斑点、皱纹、棕色斑及红色区减轻，差异有统计学意义(P0.05)。患者自我满意度调查结果显示面部色斑淡化满意度为62.76%，皮肤瘙痒刺痛减轻满意度为76.47%，皮肤紧绷感减轻满意度为88.23%，所有患者在药物使用过程中无皮肤不良反应发生。结论：重组人表皮生长因子联合舒宁乳膏对减轻黄褐斑色素及修复皮肤屏障具有一定的治疗作用。

    [关键词]重组人表皮生长因子;舒宁乳膏;黄褐斑;皮肤屏障

    [中图分类号]R758.4+2? ? ?[文献标志码]A? ? ?[文章编号]1008-6455(2021)04-0041-04

    Effect of Recombinant Human Epidermal Growth Factor Combined with Shuning Cream on Melasma and Skin Barrier

    TANG Xiao-qing， WEI Hong

    (Department of Plastic Surgery， the First Affiliated Hospital of Army Medical University，Chongqing 400038，China)

    Abstract： Objective? To observe the effect of recombinant human epidermal growth factor combined with ShuNing cream on the repair of melasma and skin barrier. Methods Thirty-four cases with melasma and skin barrier damaged were treated by the author's laser center were observed. Patients used recombinant human epidermal growth factor and Shu Ning cream twice a day ......