杨靖 谢群

    [关键词]原花青素;瘢痕疙瘩成纤维细胞;细胞增殖;细胞迁移;TLR4/MyD88通路

    [中图分类号]R619+.6? ? [文献标志码]A? ? [文章编号]1008-6455(2021)11-0085-05

    Effect of Procyanidins on the Proliferation，Migration and Tlr4/Myd88 Pathway of Keloid Fibroblasts

    YANG Jing，XIE Qun

    (Department of Plastic Surgery，Xiangyang Central Hospital，Xiangyang 441000，Hubei，China)

    Abstract： Objective? To investigate the effect of procyanidins on the proliferation， migration and TLR4/MyD88 pathway of keloid fibroblasts. Methods? Culture 96-well (5×103 cells/well) KFs cells in vitro， and determine the half inhibitory concentration of proanthocyanidin by MTT method; 96-well (5×103 cells/well) KFs cells were randomly divided into control group， low-dose proanthocyanidin group， and proanthocyanidin medium The dose group and the high-dose proanthocyanidin group ......