叶维奇 王浩 黄书润 郭少榕

    [摘要]目的：探討活性因子敷料结合负压封闭引流(Vacuum sealing drainage，VSD)对深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形的影响。方法：选取2018年6月-2021年3月收治的120例深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形患者为研究对象，采用随机数字表法分为观察组60例和对照组60例。对照组采用常规方法并VSD治疗，观察组在对照组治疗基础上联合外用活性因子敷料，两组均持续治疗14 d。治疗结束后，评估两组治疗效果，采用酶联免疫法检测血清白介素-10(Interleukin-6，IL-10)和细胞间黏附分子(Intercellular adhesion molecule 1，ICAM-1)水平，采用放射免疫法检测血清表皮生长因子(Epidermalgrowth factor，EGF)水平；比较两组治疗后1、3、6个月的瘢痕厚度。采用温哥华瘢痕量表(Vancouver scar scale，VSS)评估两组治疗前及治疗1、3、6个月烧伤部位瘢痕修复情况。结果：观察组治疗有效率为91.67%，高于对照组的78.33%(P<0.05)；观察组患者治疗后1、3、6个月的瘢痕厚度均低于对照组(P<0.05)；治疗后，观察组IL-10和EGF水平高于对照组，ICAM-1低于对照组，差异均有统计学意义(P<0.05)；治疗后1、3、6个月，观察组VSS评分均低于对照组(P<0.05)。结论：活性因子敷料结合VSD可提高深Ⅱ度烧伤创面愈合后瘢痕挛缩畸形疗效和瘢痕瘢痕挛缩畸形改善效果，安全性高。

    [关键词]活性因子敷料；负压封闭引流；深Ⅱ度烧伤；瘢痕挛缩畸形；温哥华瘢痕量表

    [中图分类号]R622? ? [文献标志码]A? ? [文章编号]1008-6455(2023)03-0038-04

    Abstract： Objective? To explore the effects of active factor dressing combined with wound vacuum sealing drainage (VSD) on scar contracture deformity after wound healing in deep degree-II burn. Methods? A total of 120 patients with scar contracture deformity after wound healing and deep degree-Ⅱ burn admitted to the hospital were enrolled as the research objects between June 2018 and March 2021.According to random number table method ......