赵慧敏 赵志祥 王雅玲 黄紫扬 简丹

    [摘要]目的：探究以羟基频哪酮视黄酸酯(Hydroxypina retinoate，HPR)为主要成分的非处方维A酸类护肤品在临床上改善皮肤早期老化征象的有效性及安全性。方法：对72例使用以HPR为主要成分护肤品的早期老化就医者进行回顾性研究。结果：使用4周后，44%的就医者皮肤整体改善度在25%以上，其中肤色、纹理、皱纹、毛孔较使用前有显著性改善(P<0.01)，并在使用8周后持续改善，且就医者耐受性良好，常见的副作用为短暂性的轻度干燥、刺痛、红斑。结论：以HPR为主要成分的护肤品对于皮肤早期老化征象具有明确改善作用，主要体现在肤色、纹理、皱纹的改善，其副作用相对可控。

    [关键词]维A酸；羟基频哪酮视黄酸酯；皮肤老化；肤色；纹理；皱纹

    [中图分类号]R758.4+2? ? [文献标志码]A? ? [文章编号]1008-6455(2023)05-0010-05

    A Retrospective Study on the Improvement Of Early Aging Signs of Skin by Skin Care Products Based on Hydroxypinacone Retinoate

    ZHAO Huimin，ZHAO Zhixiang，WANG Yaling，HUANG Ziyang，JIAN Dan

    (Department of Dermatology，Xiangya Hospital，Central South University，Changsha 410008，Hunan，China)

    Abstract： Objective? To explore the efficacy and safety of over-the-counter retinoic acid skincare products with hydroxypinone retinoate as the main component in improving the early aging signs of skin. Methods? A retrospective study was conducted on 72 early aging patients who used skin care products with HPR as the main component. Results? After 4 weeks of use ......