可注射型富血小板纤维蛋白在创面修复治疗中的应用研究进展
张颖 陈华[摘要]近年来,已经开发出不同的自体血小板浓缩物,例如富血小板血浆(Platelet-rich plasma,PRP))和富血小板纤维蛋白(Platelet-rich fibrin,PRF)。注射型富血小板纤维蛋白(Injectable platelet-rich fibrin,i-PRF)作为PRF衍生物中唯一以液体形式获得的产物,不仅保留了PRF在创面治疗中的独特优势(如:持续释放生长因子,促进新生血管生成,细胞迁移、增殖和分化),低速离心后更是显著增加了白细胞和血小板数量以及生长因子浓度。同时还可以达到最大化注射,并能够与其他生物材料联用,因此在创面修复领域受到广泛关注。本文就i-PRF在创面修复治疗中的应用现状进行综述。
[关键词]注射型富血小板纤维蛋白;创面修复;富血小板血浆;富血小板纤维蛋白
[中图分类号]R641? ? [文献标志码]A? ? [文章编号]1008-6455(2023)11-0202-03
Research Progress of Injectable Platelet-rich Fibrin in Wound Repair
ZHANG Ying,CHEN Hua
(Department of Plastic and Cosmetic Surgery,the First Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)
Abstract: In recent years, different autologous platelet concentration techniques have been developed, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF).As the only liquid product of PRF derivatives, injectable platelet-rich fibrin (i-PRF) not only retains the unique advantages of PRF in wound treatment (such as continuous release of growth factors, promoting neovascularization, cell migration ......
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