杨丹丹 沈杰 赵琪 王雍 孙振亮 胡振林

    [摘要]皮肤萎缩是外用糖皮质激素最常见的副作用之一。外用糖皮质激素引起皮肤萎缩的机制包括：抑制角质形成细胞增殖、加快其分化成熟、抑制表皮脂质合成、抑制成纤维细胞增殖，减少胶原蛋白和透明质酸钠等细胞外基质合成等。近年来，对其副作用的防治主要集中在研发糖皮质激素受体的选择性调节剂、靶向抑制促萎缩基因及相关的信号通路、联合使用其他核受体的激动剂等方面，本文就其研究进展综述如下。

    [关键词]糖皮质激素；皮肤萎缩；副作用；选择性调节剂；促萎缩基因；核受体激动剂

    [中图分类号]R322.99? ? [文献标志码]A? ? [文章编号]1008-6455(2024)01-0181-04

    Research Progress on Skin Atrophy Induced by Topical Glucocorticoids and Its Prevention and Treatment

    YANG Dandan1，SHEN Jie2，ZHAO Qi1，WANG Yong1，SUN Zhenliang2，HU Zhenlin1

    (1.School of Medicine，Shanghai University，Shanghai 200444，China; 2.Central Laboratory，Shanghai Fengxian District Central Hospital，Shanghai 201499，China)

    Abstract： Skin atrophy is one of the most prevalent side-effects of topical glucocorticosteroids. The mechanisms involved in topical glucocorticoids-induced skin atrophy include suppressing keratinocyte proliferation， accelerating their maturation， inhibiting the synthesis of epidermal lipids， suppressing fibroblast proliferation， reducing the synthesis of extracellular matrix such as collagen and hyaluronic acid， etc. In recent years ......