鲁育含 于立敏

    [摘要]压力性损伤(Pressure injury，PI)是由单独的压力或压力-剪切力联合引起的局部皮肤或下层组织缺血缺氧造成的坏死损伤，严重者可发展为难愈性压伤。随着全球老龄化的加剧，难愈性压伤已经成为世界范围内的重要健康问题，消耗了大量的医疗资源，也给医护人员带来巨大的挑战。富血小板血浆(Platelet-rich plasma，PRP)是通过离心从自身全血中分离和浓缩含血小板的血浆，富含多种生长因子及活性蛋白，能有效促进细胞的增殖分化及组织修复，现如今已作为一种新型治疗方法在再生医学领域得到广泛应用。本文主要从富血小板血浆在难愈性压伤中的应用进展及作用机制进行论述，为其在临床进一步应用提供理论基础。

    [关键词]难愈性；压伤性损伤；富血小板血浆；应用；作用机制

    [中图分类号]R641? ? [文献标志码]A? ? [文章编号]1008-6455(2024)02-0179-04

    Research Progress on the Application and Mechanism of Platelet-rich Plasma in Refractory Pressure Injury

    LU Yuhan，YU Limin

    (Department of Health，the Affiliated Hospital of Qingdao University，Qingdao 266061，Shandong，China)

    Abstract： Pressure injury (PI) is a necrotic injury caused by localized ischemia and hypoxia of the skin or underlying tissues induced either by pressure alone or pressure alone or by a combination of pressure-shear forces， and in severe cases can develop into a refractory pressure injury.With the aggravation of global aging， refractory pressure injuries have become a major health problem worldwide， consuming significant healthcare resources and posing a huge challenge to healthcare professionals. Platelet-rich plasma (PRP) is platelet-rich plasma that is isolated and concentrated by centrifugation from whole blood. PRP is rich in growth factors and active proteins ......