贾尚洁 陈涛

    [摘要]瘢痕疙瘩是皮肤科常见的一种由多种原因所致的皮肤结缔组织过度生长的良性肿瘤。微小RNA(microRNA，miRNA)是一类非编码单链RNA分子，主要参与生物基因转录后的蛋白质表达调控以及多种疾病的病理生理过程。目前，已發现miRNA的差异性表达与瘢痕疙瘩成纤维细胞的生长和侵袭、细胞外基质胶原的堆积以及血管生成相关。本文对miRNA在瘢痕疙瘩中的研究进展进行总结，以期为瘢痕疙瘩的诊治方案提供新思路。

    [关键词]微小RNA；瘢痕疙瘩；成纤维细胞；治疗靶点；细胞外基质

    [中图分类号]R619+.6? ? [文献标志码]A? ? [文章编号]1008-6455(2024)02-0195-04

    Research Status of miRNA in Keloids

    JIA Shangjie1，2，CHEN Tao1，2

    (1.Zunyi Medical University，Zunyi 563000，Guizhou，China; 2.Department of Dermatology，Chengdu Second People's Hospital，Chengdu 610000，Sichuan，China)

    Abstract： Keloid is a benign tumor common in dermatology that causes an overgrowth of connective tissue of the skin. MicroRNA (microRNA， miRNA) is a class of non-coding single-stranded RNA molecules， mainly involved in the regulation of protein expression after transcription of biological genes and the pathophysiological processes of various diseases. At present， differential expression of miRNA has been found to be associated with the growth and invasion of keloid fibroblasts， the accumulation of extracellular matrix collagen， and angiogenesis. This article will describe the research progress of miRNA in keloids ......