郑屿萍 黄清瑞 张彦峰 张慧敏 何翔

    [摘要]脱发是一种较为常见的皮肤疾病，其发病率逐年上升，并呈年轻化趋势发展，困扰着越来越多人的生活，以进行性毛囊微型化、毛发生长期缩短为特点，导致毛发附着松散容易脱落。ⅩⅦ型胶原蛋白是一种跨膜蛋白，位于表皮基底膜区的半桥粒，维持表皮真皮之间的紧密连接。近期研究发现，ⅩⅦ型胶原蛋白参与毛发生长，调节毛发相关细胞的静息与活化。若缺失ⅩⅦ型胶原蛋白可通过DNA损伤效应累积、表皮细胞极性失衡以及抑制干细胞竞争导致脱发。本文将对ⅩⅦ型胶原蛋白在脱发中的作用机制予以综述，为毛发再生领域研究提供方向。

    [关键词]ⅩⅦ型胶原蛋白；毛囊；干细胞；衰老；脱发；再生

    [中图分类号]R758.71? ? [文献标志码]A? ? [文章编号]1008-6455(2024)03-0175-04

    Research Progress on the Mechanism of Collagen Type XⅦ in Alopecia

    ZHENG Yuping，HUANG Qingrui，ZHANG Yanfeng，ZHANG Huimin，HE Xiang

    (Department of Dermatology，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China)

    Abstract： Alopecia is a common skin disease. Its incidence is increasing year by year， and it is developing in a younger trend， which is plaguing more and more people 's lives. It is characterized by progressive hair follicle miniaturization and shortening of hair growth period， resulting in loose hair attachment and easy shedding. Collagen type ⅩⅦ is a transmembrane protein located in the hemidesmosomes of the epidermal basement membrane zone ......