内皮抑素和血管抑素抑制类风湿关节炎血管发生的研究进展(1)
【摘要】血管发生在类风湿关节炎的病理过程中起着重要的作用。内皮抑素(ES)和血管抑素(AG)是内源性血管发生抑制剂,能特异地抑制血管内皮细胞的增殖和迁移、并诱导内皮细胞凋亡,从而发挥抗血管发生的作用。本文就它们的结构、作用机制以及对RA血管发生的影响进行综述。【关键词】血管发生;类风湿关节炎;内皮抑素;血管抑素
【中图分类号】R593.22 【文献标识码】B 【文章编号】1008-6455(2010)07-0123-03
Research advancement of Endostatin and angiostatin in suppression angiogenesis on rheumatoid arthritis
Summarize: Ma Qiang1 proof-reader:Liu Qingsong1 Tang Zhong1,2
【Abstract】Angiogenesis is important in the process of rheumatoid arthritis. Angiostatin and endostatin are endogenous angiogenesis inhibitors, which play the role of anti-angiogenesis by specifically inhibit proliferation and migration, and induce apoptosis of vascular endothelial cell. This view focuses on the structure, mechanism and the impact on RA of angiostatin and endostatin.
【Key words】angiogenesis; rheumatoid arthritis; angiostatin; endostatin
类风湿性关节炎(rheumatoid arthritis,RA)病理变化为持续性滑膜炎及血管翳形成,尤其依赖于广泛的新生血管网的形成 ......
您现在查看是摘要页,全文长 5009 字符。