奥美拉唑\多潘立酮\多虑平三联法治疗功能性消化不良的疗效分析(1)
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【摘要】目的：观察奥美拉唑、多潘立酮、多虑平三联法治疗功能性消化不良的疗效与安全性。方法：将120例功能性消化不良的患者随机分为治疗组和对照组。对照组60例，予多潘立酮、多虑平治疗；治疗组60例，给予多奥美拉唑、多潘立酮、多虑平三联法治疗，两组疗程均为3周。结果：治疗组治愈率为21.7%，总有效率为95.0%，对照组治愈率为11.7%，总有效率为81.7%，有统计学意义，P<0.05。不良反应发生率治疗组6.67%，对照组为5.00%，两组比较差异无统计学意义。 结论：奥美拉唑、多潘立酮、多虑平三联法治疗功能性消化不良疗效显著，依从性好，不良反应发生率低，治疗功能性消化不良安全有效。
【关键词】功能性消化不良；奥美拉唑；多潘立酮；多虑平；三联疗法
【中图分类号】R57【文献标识码】B【文章编号】1008-6455(2011)08-0346-02
Analysis of the Efficacy of Domperidone, Doxepine Combined Omeprazole on the Functional Dyspepsia
Dang Haiyan
【Abstract】Objective：To observe the efficacy and safety of Domperidone,Doxepine Combined Omeprazole in the treatment of functional dyspepsia(FD). Methods：120 paitients with FD were divided into two groups randomly. The treatment group(n60) were given Domperidone, Doxepine Combined Omeprazole while the control group (n60) were given Domperidone and Doxepine for 3 weeks. Results：After 3-week treatment, the cure rate and the total effective rate in the treatment group is 21.7% and 95.0%, respectively, compared to that of 11.7% and 81.7% in the observation group, and there are significantly statistically difference between the two groups, (P<0.05). The incidence of adverse reactions is 6.67% in treatment group, compared to that of 5.00% in control group, and there are no significantly statistically difference between the two groups, (P>0.05). Conclusion：The Combination therapy of Domperidone, Doxepine and Omeprazole in the treatment of functional dyspepsia(FD) has advantages such as distinct efficacy, good compliance, and low incidence of adverse reactions. The Combination therapy is effect and safe in the treatment of functional dyspepsia(FD).
【Key words】Functional Dyspepsia；Omeprazole; Domperidone; Doxepine; Triple Therapy
功能性消化不良(FD)是一种非常多见的症侯群，在消化内科疾病中约占50%[1]，主要临床表现为上腹部疼痛、腹胀、早饱、食欲不振、嗳气、恶心、呕吐等症状[2]，随着病情进展，患者还可能产生上腹部烧灼感和反酸等症状，且有不少患者同时伴有失眠、焦虑、抑郁、头痛、注意力不集中等精神症状。研究表明，FD与胃肠动力异常、精神状态、应激因素有密切关系，对患者的生活质量产生严重的影响。 笔者回顾分析120例FD患者临床采用奥美拉唑、多潘立酮、多虑平三联法治疗FD，取得理想疗效，报道如下。
1 资料和方法
1.1 临床资料:自1996年6月至2000年6月我市医院入院及门诊的FD患者均符合国际公认的诊断标准[3]。①慢性上腹部疼痛、腹胀、早饱、烧心、返酸、嗳气、恶心或呕吐症症状持续4周以上；②内镜下表现为胃十二指肠正常或排除糜烂、溃疡及肿瘤等器质性病变；③肝功能、B超等除外肝、胆、胰病变；④除外甲状腺机能抗进患者、妊娠或哺乳期妇女 ......
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