王 颖 王永才 王忠利 赵成艳 王 敏

    【摘要】 目的 探讨CD55、CD59、CD34抗原对阵发性血红蛋白尿(PNH)的早期诊断的价值，寻找PNH早期诊断敏感指标进而达到早期发现、早期诊断、早期治疗的目的。方法 应用流式细胞仪测定PNH综合症患者的CD55、CD59、CD34抗原变化关系，并与PNH、AA等疾病组以及正常对照组CD55、CD59、CD34抗原相互变化关系，经过统计学处理，找出相关性。结果 结果表明PNHCD55、CD59、CD34抗原较AA及其他疾病组及正常对照组明显减低，并与溶血程度呈正相关，且早于其他溶血指标。结论 CD55、CD59、CD34抗原表达率可做PNH早期诊断最敏感指标，并与预后转归密切相关。

    关键词：CD55 CD59 CD34 PNH 诊断

    文章编号：1008-6919(2006)07-0070-03

    中图分类号:R730.21

    文献标识码：A

    The study of application of CD55、CD59、CD34 on the early diagnosis of PNH

    [ Abstract ] ObjectiveTo study the significance of CD55、CD59 and CD34 in the early diagnosis of paroxysmal nocmmal hemoglobin nuria(PNH),and to search for a sensitive marker of the early diagnosis , so as to achieve the objective of early fmding, early diagnosis and early treatment.MethodCD55、CD59 and CD34 in PNH were detected by Flow cytometry, the relationship among CD55、CD59 and CD34 in PNH, AA patients and control group were studied to fred out their statistic relevance.ResultThe levels of CD55、CD59 and CD34 of PNH were significantly lower those AA, of group and any other diseases and control group, the markers were positively correlated with hemolysis degree and their increase were earlier than other markers of hemolysis.ConclusionCD55、CD59 and CD34 antigens may act as the most sensitive marker of early diagnosis in PNH syndrome, and have a close correlation with prognosis. ......