葛根素对两肾一夹高血压大鼠左心室Apekin/APJ基因表达的影响(3)
本实验提示,葛根素具有逆转高血压大鼠左室肥厚的作用，该作用至少部分是通过apelin –APJ信号系统来实现的，而其具体作用机制尚有待于进一步深入探讨。
参考文献
[1] 胡瑞,张象贤,王亚芬,等，氯沙坦对原发性高血压患者左室肥厚逆转作用观察[J].国外医学•心血管疾病分册,2001,28(2):1061.
[2] Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor [J].Biochem Biophy Res commun,1998,251(2):471-476.
[3] Oudit GY,Crackower MA,Backx PH, et al. The role of ACE2 in cardiovascular physiology[J].Trends Cardiovasc Med,2003,13:93-101.
[4] Berry M K，Pirolli T J，Jayasankar V, et a1.Apelin has vivo inotropic effects on normal and failing hearts[J].Circulation,2004,110(11 Suppl 1):11187-11193.
[5] O’carroll A M,Selby T L,Palkovits M, et a1.Distribution of mRNA encoding B78/apj,the rat homologue of the human APJ receptor,and its endogenous ligand apelin in brain and peripheral tissues[J].Biochim Biophys Acta,2000,1492(1):72-80.
[6] 傅继华, 陈宇飞, 张琪.肾性高血压大鼠实验模型制作改进[J].中国药科大学学报, 1995,26(6):383-384.
[7] 谢克俭,潘芙蓉,曾焕森,等. 一氧化氮和内皮素在高血压左室肥厚形成中的作用[J].山东医药,2006, 46(11) :13-14.
[8] Szokodi I, Tavi P, Fldes G, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility[J]. Circulation Research, 2002, 91:434-440.
[9] Jia YX, Pan CS, Zhang J, et al. Apelin protects myocardial injury induced by isoproterenol in rats[J]. Regul Pept,2006，133(1/3):147-154.
[10] Chen MM, Ashley EA, Deng DXF, et al. Novel role for the potent endogenous in otrope apelin in human cardiac dysfunction[J]. Circulation, 2003, 108:1432-1439.
[11] 江志平,肖立中,徐新,等.葛根素对高血压病患者左室肥厚的影响[J].实用心脑肺血管病杂志,2004,12(5):260-262., 百拇医药(金 戈 杨鹏麟 龚永生 范小芳 庄 红)
参考文献
[1] 胡瑞,张象贤,王亚芬,等，氯沙坦对原发性高血压患者左室肥厚逆转作用观察[J].国外医学•心血管疾病分册,2001,28(2):1061.
[2] Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor [J].Biochem Biophy Res commun,1998,251(2):471-476.
[3] Oudit GY,Crackower MA,Backx PH, et al. The role of ACE2 in cardiovascular physiology[J].Trends Cardiovasc Med,2003,13:93-101.
[4] Berry M K，Pirolli T J，Jayasankar V, et a1.Apelin has vivo inotropic effects on normal and failing hearts[J].Circulation,2004,110(11 Suppl 1):11187-11193.
[5] O’carroll A M,Selby T L,Palkovits M, et a1.Distribution of mRNA encoding B78/apj,the rat homologue of the human APJ receptor,and its endogenous ligand apelin in brain and peripheral tissues[J].Biochim Biophys Acta,2000,1492(1):72-80.
[6] 傅继华, 陈宇飞, 张琪.肾性高血压大鼠实验模型制作改进[J].中国药科大学学报, 1995,26(6):383-384.
[7] 谢克俭,潘芙蓉,曾焕森,等. 一氧化氮和内皮素在高血压左室肥厚形成中的作用[J].山东医药,2006, 46(11) :13-14.
[8] Szokodi I, Tavi P, Fldes G, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility[J]. Circulation Research, 2002, 91:434-440.
[9] Jia YX, Pan CS, Zhang J, et al. Apelin protects myocardial injury induced by isoproterenol in rats[J]. Regul Pept,2006，133(1/3):147-154.
[10] Chen MM, Ashley EA, Deng DXF, et al. Novel role for the potent endogenous in otrope apelin in human cardiac dysfunction[J]. Circulation, 2003, 108:1432-1439.
[11] 江志平,肖立中,徐新,等.葛根素对高血压病患者左室肥厚的影响[J].实用心脑肺血管病杂志,2004,12(5):260-262., 百拇医药(金 戈 杨鹏麟 龚永生 范小芳 庄 红)