卵蛋白致敏新西兰家兔建立支气管哮喘模型(1)
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(1.北京中医药大学,北京 100029；2.中日友好医院国家中医药管理局重点研究室，北京 100029)
摘 要：目的：观察新西兰家兔腹腔注射卵蛋白后静脉血、支气管肺泡灌洗液嗜酸粒细胞计数的表达以及家兔症状表现。方法：实验家兔分为两组，即空白对照组和模型组。模型组家兔腹腔注射10%卵蛋白(OVA)，空白对照组家兔腹腔注射等剂量生理盐水，14天后模型组用1%OVA连续雾化7天诱发其哮喘发作，空白对照组则给予生理盐水雾化吸入。结果：模型组家兔出现明显腹肌抽搐、烦躁、二便失禁等症状；模型组家兔静脉血以及支气管肺泡灌洗液中的嗜酸粒细胞计数与空白对照组相比明显升高。结论：新西兰家兔腹腔注射卵蛋白成功建立支气管哮喘模型。
关键词：卵蛋白；新西兰家兔；支气管哮喘；模型
中图分类号：R-33文献标识码：A文章编号：1673-7717(2011)03-0473-03
Giving New Zealand Rabbits Celiac Injection With Ovalbumin
To Simulate Bronchial Asthma Model
CHEN Xin-xin1, LI You-lin2
(1.Medical Doctoral Student of 2008 of Beijing University of Traditional Chinese Medicine，Beijing 100029,China;
2.Focus Investigatory Office of China-Japan Friendship Hospital and State Administration
of Traditional Chinese Medicine of the People's Republic of China, Beijing 100029,China)
Abstract:Objective:To observing the number of acidophil in venous blood and bronchia alveolar fluid and the symptom of New Zealand rabbits after injecting ovalbumin. Methods:These rabbits are divided into controlled team and intervened team. The intervened team rabbits are injected with 10%OVA but the controlled team are injected with 95%NaCl.After 14 days, we cause the intervened team rabbits asthma with inhaling 1%OVA. The controlled team rabbits inhaling 95%NaCl.Results：The intervened team rabbits appearing the symptom of convulsion, dysthesia, urinary and fecal incontinence,etc. The number of acidophil in the intervened team rabbits'venous blood and bronchia alveolar fluid more than the controlled team rabbits.Conclusion:We Simulate New Zealand Rabbits bronchial asthma model with injecting ovalbumin in celiac successfully.
Key words:ovalbumin；New Zealand rabbits；bronchial asthma；model
收稿日期：2010-10-28
基金项目：国家自然科学基金资助项目(30772096)
作者简介：陈馨馨(1981-) ......
(1.北京中医药大学,北京 100029；2.中日友好医院国家中医药管理局重点研究室，北京 100029)
摘 要：目的：观察新西兰家兔腹腔注射卵蛋白后静脉血、支气管肺泡灌洗液嗜酸粒细胞计数的表达以及家兔症状表现。方法：实验家兔分为两组，即空白对照组和模型组。模型组家兔腹腔注射10%卵蛋白(OVA)，空白对照组家兔腹腔注射等剂量生理盐水，14天后模型组用1%OVA连续雾化7天诱发其哮喘发作，空白对照组则给予生理盐水雾化吸入。结果：模型组家兔出现明显腹肌抽搐、烦躁、二便失禁等症状；模型组家兔静脉血以及支气管肺泡灌洗液中的嗜酸粒细胞计数与空白对照组相比明显升高。结论：新西兰家兔腹腔注射卵蛋白成功建立支气管哮喘模型。
关键词：卵蛋白；新西兰家兔；支气管哮喘；模型
中图分类号：R-33文献标识码：A文章编号：1673-7717(2011)03-0473-03
Giving New Zealand Rabbits Celiac Injection With Ovalbumin
To Simulate Bronchial Asthma Model
CHEN Xin-xin1, LI You-lin2
(1.Medical Doctoral Student of 2008 of Beijing University of Traditional Chinese Medicine，Beijing 100029,China;
2.Focus Investigatory Office of China-Japan Friendship Hospital and State Administration
of Traditional Chinese Medicine of the People's Republic of China, Beijing 100029,China)
Abstract:Objective:To observing the number of acidophil in venous blood and bronchia alveolar fluid and the symptom of New Zealand rabbits after injecting ovalbumin. Methods:These rabbits are divided into controlled team and intervened team. The intervened team rabbits are injected with 10%OVA but the controlled team are injected with 95%NaCl.After 14 days, we cause the intervened team rabbits asthma with inhaling 1%OVA. The controlled team rabbits inhaling 95%NaCl.Results：The intervened team rabbits appearing the symptom of convulsion, dysthesia, urinary and fecal incontinence,etc. The number of acidophil in the intervened team rabbits'venous blood and bronchia alveolar fluid more than the controlled team rabbits.Conclusion:We Simulate New Zealand Rabbits bronchial asthma model with injecting ovalbumin in celiac successfully.
Key words:ovalbumin；New Zealand rabbits；bronchial asthma；model
收稿日期：2010-10-28
基金项目：国家自然科学基金资助项目(30772096)
作者简介：陈馨馨(1981-) ......
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