中药联用厄贝沙坦治疗糖尿病肾病微量白蛋白尿期的疗效观察(1)
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(宁海中医院糖尿病中心，浙江 宁海 315600)
摘 要：目的：探讨中药联用厄贝沙坦治疗糖尿病肾病(DN)微量白蛋白尿期的疗效和作用机制。方法：将糖尿病微量白蛋白尿期患者88例随机分成治疗组与对照组，每组44例，对照组给予糖尿病饮食、控制血糖及口服厄贝沙坦片等常规治疗，治疗组在常规治疗的基础上加用中药口服。两组均以6周为1个疗程。观察两组治疗前后ACR(尿白蛋白与肌酐的比值)、尿素氮、血肌酐、血脂、血糖、糖化血红蛋白、丙二醛、超氧化物歧化酶、CRP等指标变化。结果：治疗组治疗后除尿素氮、血肌酐、糖化血红蛋白等外其他各项指标与对照组比较均有明显改善(P<0.01)。结论：中药联用厄贝沙坦有较好的降低尿微量白蛋白及改善血糖血脂的作用。
关键词：糖尿病肾病；微量白蛋白尿；中药；厄贝沙坦
中图分类号：R587.1文献标识码：B文章编号：1673-7717(2011)03-0540-03
Observation of Combining Chinese Herbal Medicine with Irbesartan Early
Stage Diabetic Nephrosis
BAO Hong-juan
(Department of Internal medicine,Ninghai Hospitol of TCM, Ninghai 315600, Zhejiang, China)
Abstract:Objective：To inquire into the therapeutic effect and mechanisms of chinese herbal medicine combined with irbesartan for treatment of early stage diabetic nephropathy. Methods：88 patients with early stage diabetic nephrosis were randomly divided into 2 groups. The control group(n44) was treated with irbesartan, diabetic diet, controlling glucose etc.The treatment group(n44) treated with chinese herbal medicine.Six weeks constituted one course. Changes of urea nitrogen, serum creatinie, blood lipid, glycosylated hemoglobin，MDA,SOD,CRP and ACR before and after treatment were investigated. Results：After treatment, investigated indexes except urea nitrogren ,serum creatinine and glycosylated hemoglobin, improved significantly in the treatment group(P<0.01).Conclusion：chinese herbal medicine and irbesartan can markedly decrease ACR.
Key words:diabetic nephropathy；trace albumen urine；chinese herbal medicine；irbesartan
尿微量白蛋白指的是尿白蛋白与肌酐比值(ACR)在30～300mg/g之间 ......
(宁海中医院糖尿病中心，浙江 宁海 315600)
摘 要：目的：探讨中药联用厄贝沙坦治疗糖尿病肾病(DN)微量白蛋白尿期的疗效和作用机制。方法：将糖尿病微量白蛋白尿期患者88例随机分成治疗组与对照组，每组44例，对照组给予糖尿病饮食、控制血糖及口服厄贝沙坦片等常规治疗，治疗组在常规治疗的基础上加用中药口服。两组均以6周为1个疗程。观察两组治疗前后ACR(尿白蛋白与肌酐的比值)、尿素氮、血肌酐、血脂、血糖、糖化血红蛋白、丙二醛、超氧化物歧化酶、CRP等指标变化。结果：治疗组治疗后除尿素氮、血肌酐、糖化血红蛋白等外其他各项指标与对照组比较均有明显改善(P<0.01)。结论：中药联用厄贝沙坦有较好的降低尿微量白蛋白及改善血糖血脂的作用。
关键词：糖尿病肾病；微量白蛋白尿；中药；厄贝沙坦
中图分类号：R587.1文献标识码：B文章编号：1673-7717(2011)03-0540-03
Observation of Combining Chinese Herbal Medicine with Irbesartan Early
Stage Diabetic Nephrosis
BAO Hong-juan
(Department of Internal medicine,Ninghai Hospitol of TCM, Ninghai 315600, Zhejiang, China)
Abstract:Objective：To inquire into the therapeutic effect and mechanisms of chinese herbal medicine combined with irbesartan for treatment of early stage diabetic nephropathy. Methods：88 patients with early stage diabetic nephrosis were randomly divided into 2 groups. The control group(n44) was treated with irbesartan, diabetic diet, controlling glucose etc.The treatment group(n44) treated with chinese herbal medicine.Six weeks constituted one course. Changes of urea nitrogen, serum creatinie, blood lipid, glycosylated hemoglobin，MDA,SOD,CRP and ACR before and after treatment were investigated. Results：After treatment, investigated indexes except urea nitrogren ,serum creatinine and glycosylated hemoglobin, improved significantly in the treatment group(P<0.01).Conclusion：chinese herbal medicine and irbesartan can markedly decrease ACR.
Key words:diabetic nephropathy；trace albumen urine；chinese herbal medicine；irbesartan
尿微量白蛋白指的是尿白蛋白与肌酐比值(ACR)在30～300mg/g之间 ......
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