醒脑静注射液对高血氨大鼠空间学习记忆能力的影响(1)
参见附件(12kb)。
(1.温州医学院附属第二医院感染中医病区，浙江 温州 325000； 2.温州医学院附属第一医院，浙江 温州 325000)
摘 要：目的：探讨醒脑静注射液对高血氨大鼠空间学习记忆功能的影响。方法：清洁级雄性SD大鼠30只，随机分为3组：A组 (正常对照组，n10),B组(高血氨模型组，n10)，C组(醒脑静治疗组，n10)，Morris水迷宫观察动物空间学习记忆的变化。结果：与正常对照组比较，高血氨模型组及醒脑静治疗组大鼠血氨水平明显升高；但与高血氨模型组相比，醒脑静治疗组大鼠寻找障台的平均逃避潜伏期、游泳总距离均缩短。结论：醒脑静一定程度上改善了高血氨大鼠空间学习记忆能力。
关键词：醒脑静；血氨；水迷宫；学习记忆
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2011)03-0585-03
Effect of Xingnaojing on Spatial Learning-and-Memory Ability
in Rats with Higher level Blood Ammonia
PAN Chen-wei1, PAN Zhen-zhen2,CHEN Yong-ping2，LIN Shi-yi1,ZHUGE Lu1,JIN Ling-xiang1
(1.2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,Zhejiang,China;
2.First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,Zhejiang,China)
Abstract:Objective: To investigate Effect of Xingnaojing injection on spatial learning-and-Memory ability in rats with Higher level Blood ammonia. Methods:Thirty clean-grade SD (Sprague Dawley) male rats was divided into three groups randomly: A group (normal control, n10) andB group (Higher level Blood ammonia model, n10)and C group (treated by Xingnaojing injection, n10).Then the rats were observed on variation of spatial learning-and-Memory through Morris water maze.Results:Compared with rats of normal control group, the ones in two other groups had higer level blood ammonia obviously; And compared with rats of Higher level Blood ammonia model groop, the ones treated by Xingnaojing show evidently improved performance of the test. Conclusion:Xingnaojing injection could improve spatial learning-and-Memory ability in rats with Higher level Blood ammonia.
Key words:Xingnaojing；Blood ammonia；Water maze；Learning-and-memory
收稿日期：2010-10-26
基金项目：浙江省自然基金资助项目(Y207464)； 浙江省引进国外技术、管理人才项目(Y2004GY031)；温州市科技计划项目(Y20100247)
作者简介：潘陈为(1980-) ......
(1.温州医学院附属第二医院感染中医病区，浙江 温州 325000； 2.温州医学院附属第一医院，浙江 温州 325000)
摘 要：目的：探讨醒脑静注射液对高血氨大鼠空间学习记忆功能的影响。方法：清洁级雄性SD大鼠30只，随机分为3组：A组 (正常对照组，n10),B组(高血氨模型组，n10)，C组(醒脑静治疗组，n10)，Morris水迷宫观察动物空间学习记忆的变化。结果：与正常对照组比较，高血氨模型组及醒脑静治疗组大鼠血氨水平明显升高；但与高血氨模型组相比，醒脑静治疗组大鼠寻找障台的平均逃避潜伏期、游泳总距离均缩短。结论：醒脑静一定程度上改善了高血氨大鼠空间学习记忆能力。
关键词：醒脑静；血氨；水迷宫；学习记忆
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2011)03-0585-03
Effect of Xingnaojing on Spatial Learning-and-Memory Ability
in Rats with Higher level Blood Ammonia
PAN Chen-wei1, PAN Zhen-zhen2,CHEN Yong-ping2，LIN Shi-yi1,ZHUGE Lu1,JIN Ling-xiang1
(1.2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,Zhejiang,China;
2.First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,Zhejiang,China)
Abstract:Objective: To investigate Effect of Xingnaojing injection on spatial learning-and-Memory ability in rats with Higher level Blood ammonia. Methods:Thirty clean-grade SD (Sprague Dawley) male rats was divided into three groups randomly: A group (normal control, n10) andB group (Higher level Blood ammonia model, n10)and C group (treated by Xingnaojing injection, n10).Then the rats were observed on variation of spatial learning-and-Memory through Morris water maze.Results:Compared with rats of normal control group, the ones in two other groups had higer level blood ammonia obviously; And compared with rats of Higher level Blood ammonia model groop, the ones treated by Xingnaojing show evidently improved performance of the test. Conclusion:Xingnaojing injection could improve spatial learning-and-Memory ability in rats with Higher level Blood ammonia.
Key words:Xingnaojing；Blood ammonia；Water maze；Learning-and-memory
收稿日期：2010-10-26
基金项目：浙江省自然基金资助项目(Y207464)； 浙江省引进国外技术、管理人才项目(Y2004GY031)；温州市科技计划项目(Y20100247)
作者简介：潘陈为(1980-) ......
您现在查看是摘要介绍页，详见PDF附件(12kb)。