健脾通窍丸对AR模型大鼠血清总IgE\IL-4含量的影响(1)
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(武汉市中医医院，湖北 武汉 430014)
摘 要：目的：探讨健脾通窍丸治疗治疗变应性鼻炎的作用机理。方法：按参考文献复制变应性鼻炎大鼠模型，观察健脾通窍丸对大鼠鼻部症状、血清总IgE、IL-4含量的影响。结果：健脾通窍丸对大鼠鼻部症状有明显的抑制作用，能显著降低总IgE、IL-4值，与模型组比较，差异非常显著(P<0.01)；治疗组与阳性对照组比较，差异不显著(P>0.05)。结论：健脾通窍丸对变应性鼻炎具有治疗作用，其作用机理与抑制血清总IgE、IL-4值的产生有关。
关键词：健脾通窍丸；变应性鼻炎大鼠模型；实验研究
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2011)03-0589-02
Effect of Jianpi Tongqiao Pill to Serum Total IgEIL-4 Content of Rat Model of AR
LI Guo-yun,WANG Jin-jun,HU Xi-yuan,CHEN Li-chuan
(Wuhan Hospital of TCM,Wuhan 430014,Hubei,China)
Abstract:Objective: To explore the Jianpi Tongqiao pill treatment of allergic rhinitis treatment mechanism. Methods:According to the reference copy of allergic rhinitis rats were observed for the rat Jianpi Tongqiao pill nasal symptoms, serum total IgE, IL-4 content.Results:rats on the Jianpi Tongqiao pill nasal symptoms significantly inhibited to a significant reduction in total IgE, IL-4 value, compared with the model group, the difference was significant (P<0.01); in the treatment group and the positive control group , No significant difference (P>0.05). Conclusion: Jianpi Tongqiao pill for the treatment of allergic rhinitis have a role and mechanism of inhibition of serum total IgE, IL-4 production-related value.
Key words:Jianpi Tongqiao pill；rat model of allergic rhinitis；Experimental Research
收稿日期：2010-10-09
基金项目：武汉市卫生局科研基金项目(武卫函[2007]47号)
作者简介：李国云，女，主任医师，硕士研究生导师，研究方向：过敏性鼻炎的中西医结合治疗与研究。
健脾通窍丸是以临床经验方为基础，采用现代中药制备工艺研制的中药复方制剂，具有健脾补肺，祛风通窍之功，用于治疗脾肺气虚型变应性鼻炎疗效较好。为进一步验证其作用机理，特开展健脾通窍丸治疗治疗脾肺气虚型变应性鼻炎的实验研究，现将部分实验结果总结如下 ......
(武汉市中医医院，湖北 武汉 430014)
摘 要：目的：探讨健脾通窍丸治疗治疗变应性鼻炎的作用机理。方法：按参考文献复制变应性鼻炎大鼠模型，观察健脾通窍丸对大鼠鼻部症状、血清总IgE、IL-4含量的影响。结果：健脾通窍丸对大鼠鼻部症状有明显的抑制作用，能显著降低总IgE、IL-4值，与模型组比较，差异非常显著(P<0.01)；治疗组与阳性对照组比较，差异不显著(P>0.05)。结论：健脾通窍丸对变应性鼻炎具有治疗作用，其作用机理与抑制血清总IgE、IL-4值的产生有关。
关键词：健脾通窍丸；变应性鼻炎大鼠模型；实验研究
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2011)03-0589-02
Effect of Jianpi Tongqiao Pill to Serum Total IgEIL-4 Content of Rat Model of AR
LI Guo-yun,WANG Jin-jun,HU Xi-yuan,CHEN Li-chuan
(Wuhan Hospital of TCM,Wuhan 430014,Hubei,China)
Abstract:Objective: To explore the Jianpi Tongqiao pill treatment of allergic rhinitis treatment mechanism. Methods:According to the reference copy of allergic rhinitis rats were observed for the rat Jianpi Tongqiao pill nasal symptoms, serum total IgE, IL-4 content.Results:rats on the Jianpi Tongqiao pill nasal symptoms significantly inhibited to a significant reduction in total IgE, IL-4 value, compared with the model group, the difference was significant (P<0.01); in the treatment group and the positive control group , No significant difference (P>0.05). Conclusion: Jianpi Tongqiao pill for the treatment of allergic rhinitis have a role and mechanism of inhibition of serum total IgE, IL-4 production-related value.
Key words:Jianpi Tongqiao pill；rat model of allergic rhinitis；Experimental Research
收稿日期：2010-10-09
基金项目：武汉市卫生局科研基金项目(武卫函[2007]47号)
作者简介：李国云，女，主任医师，硕士研究生导师，研究方向：过敏性鼻炎的中西医结合治疗与研究。
健脾通窍丸是以临床经验方为基础，采用现代中药制备工艺研制的中药复方制剂，具有健脾补肺，祛风通窍之功，用于治疗脾肺气虚型变应性鼻炎疗效较好。为进一步验证其作用机理，特开展健脾通窍丸治疗治疗脾肺气虚型变应性鼻炎的实验研究，现将部分实验结果总结如下 ......
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