中药治疗痛风临床疗效Meta分析(1)
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(1.南京医科大学第一附属医院，江苏 南京 210029；2.南京中医药大学，江苏 南京 210046)
摘 要：目的：系统评价中药治疗痛风的疗效及安全性。方法：全面检索已发表的中医药治疗痛风临床试验的相关文献，采用RevMan4.2软件对其统计分析。结果：共有25个随机对照试验1750例病人满足纳入标准。与西药组相比，中药治疗痛风有效率的合并检验分析结果为：Z4.69，P﹤0.00001，合并后的RR值为1.08，95%的可信区间为(1.05，1.11)；药物不良反应发生率的比较综合检验结果为:Z11.37，P﹤0.00001，合并后的OR值为0.05，95%的可信区间为(0.03，0.08)。结论：中药治疗痛风有较好的疗效和较低的不良反应发生率。
关键词：中药；痛风；系统评价；Meta分析
中图分类号：R259.897文献标识码：A文章编号：1673-7717(2011)03-0666-05
Meta-Analysis on Clinical Therapeutic Effects of TCM on Gout
YUAN Hong-yu 1，HE Miao2，OU Ning1
(1.The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029，Jiangsu,China;
2.Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China)
Abstract:Objective:To assess the efficacy and safety of TCM for gout systematically. Methods The pertinent literatures of TCM for gout searched by electronic databases were analyzed with RevMan4.2. Results:Twenty-five randomized controlled trials with 1750 patients were met the inclusion criteria.Compared with chemical medicine, the combined statistical result of efficiency rate of TCM was Z4.69,P﹤0.00001,RR1.08 (95% CI, 1.05 to 1.11), that of ADR was Z11.37,P﹤0.00001,OR0.05,(95% CI,0.03 to 0.08).Conclucion:There were better therapeutic effect and lower incidence of ADR of TCM on gout.
Key words:TCM；Gout；System evaluation；Meta analysis
痛风是嘌呤代谢紊乱或尿酸排泄减少所引起的一组疾病，临床表现为特征性反复发作的急性关节炎，痛风石沉积，痛风性慢性关节炎和关节畸形，常累及肾脏，引起慢性间质性肾炎和尿酸性尿路结石形成，严重时可出现关节毁损致残，肾功能不全。中药对于痛风病的治疗有着悠久的历史，临床上也有一些独特的效果。但这些研究的质量和疗效尚未得到系统的评价 ......
(1.南京医科大学第一附属医院，江苏 南京 210029；2.南京中医药大学，江苏 南京 210046)
摘 要：目的：系统评价中药治疗痛风的疗效及安全性。方法：全面检索已发表的中医药治疗痛风临床试验的相关文献，采用RevMan4.2软件对其统计分析。结果：共有25个随机对照试验1750例病人满足纳入标准。与西药组相比，中药治疗痛风有效率的合并检验分析结果为：Z4.69，P﹤0.00001，合并后的RR值为1.08，95%的可信区间为(1.05，1.11)；药物不良反应发生率的比较综合检验结果为:Z11.37，P﹤0.00001，合并后的OR值为0.05，95%的可信区间为(0.03，0.08)。结论：中药治疗痛风有较好的疗效和较低的不良反应发生率。
关键词：中药；痛风；系统评价；Meta分析
中图分类号：R259.897文献标识码：A文章编号：1673-7717(2011)03-0666-05
Meta-Analysis on Clinical Therapeutic Effects of TCM on Gout
YUAN Hong-yu 1，HE Miao2，OU Ning1
(1.The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029，Jiangsu,China;
2.Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China)
Abstract:Objective:To assess the efficacy and safety of TCM for gout systematically. Methods The pertinent literatures of TCM for gout searched by electronic databases were analyzed with RevMan4.2. Results:Twenty-five randomized controlled trials with 1750 patients were met the inclusion criteria.Compared with chemical medicine, the combined statistical result of efficiency rate of TCM was Z4.69,P﹤0.00001,RR1.08 (95% CI, 1.05 to 1.11), that of ADR was Z11.37,P﹤0.00001,OR0.05,(95% CI,0.03 to 0.08).Conclucion:There were better therapeutic effect and lower incidence of ADR of TCM on gout.
Key words:TCM；Gout；System evaluation；Meta analysis
痛风是嘌呤代谢紊乱或尿酸排泄减少所引起的一组疾病，临床表现为特征性反复发作的急性关节炎，痛风石沉积，痛风性慢性关节炎和关节畸形，常累及肾脏，引起慢性间质性肾炎和尿酸性尿路结石形成，严重时可出现关节毁损致残，肾功能不全。中药对于痛风病的治疗有着悠久的历史，临床上也有一些独特的效果。但这些研究的质量和疗效尚未得到系统的评价 ......
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