宣肺中药对小鼠肠道传输功能减缓的调节作用(1)
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摘 要：目的：观察便秘模型小鼠肠道传输功能改变及加味桔梗汤的干预效果，为开展便秘“从肺论治”相应效应机制研究、探讨“肺合大肠”相关生物学基础奠定基础。方法：40只小鼠随机分为正常组、模型组、模型给药组及正常给药组，采用自身粪便与复方地芬诺酯灌胃法建立小鼠复合便秘模型。模型给药组及正常给药组以加味桔梗汤灌胃，正常组、模型组灌胃蒸馏水，连续7天，观察小鼠的排便情况及小肠推进率。结果：与正常组比较，模型组小鼠首粒黑便时间延长，4h排便粒数、4h排便重量、小肠炭末推进率均明显减少(P<0.01或P<0.05)。与模型组比较，模型给药组小鼠首粒黑便时间缩短，4h排便粒数、4h排便重量、小肠炭末推进率增加(P<0.05)。正常组与正常给药组未见显著性差异。结论：采用自身粪便与复方地芬诺酯灌胃法制备的小鼠复合便秘模型，存在明显肠道传输功能障碍；加味桔梗汤宣肺降气，可以促进胃肠蠕动、改善便秘小鼠肠道的传输功能。
关键词：便秘；传输；宣肺；肺合大肠
中图分类号：R285.5 文献标识码：A 文章编号：1673-7717(2011)04-0731-03
Effects of facilitating lung on transmission function of intestine in mice with constipation
WANG Yi, LI Yu-hang, ZHENG Feng-jie,XU Hong, GAO Yu-shan, , SUN Yan, , XU Yun, LIN Jun-sheng
(School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029，China)
Abstract:Objective: To observe the influence of facilitating lung on transmission function of intestine in mice with constipation, and to investigate the mechanism of the treatment on constipation by facilitating lung. Methods: All mice were randomly divided into normal control group, model group, treating group, and normal treating group. The mice model of constipation was established by using Compound Diphenoxylate. The model group and the normal control group were given intragastrically the distilled water, and other groups were given the modified Jiegeng Decoction intragastrically for 7 days. Detecting transmission function of intestine. Results: Compared with the normal control group, the time of the first black feces, the feces quantity within 4 hours, and the promoting rate of ink were significant difference in model group (P<0.01, or P<0.05) compared with the model group, there were significant improvement in treating group (P<0.05). Conclusion: The modified Jiegeng Decoction can enhance the improving in transmission function of intestine in mice with constipation.
Key words:constipation transmission function of intestine facilitating lung lung associated with large intestine
便秘，是临床上常见的消化道症状，主要表现为排便困难，便质干燥坚硬，秘结不通，排便次数减少或排便间隔时间延长或质软、有便意而排便困难。其发病率高，病因复杂，现代医学多采用泻药、促动力药、灌肠与手术等方法与手段治疗，但易产生依赖或耐受【sup】[1]【/sup】。临床资料表明，在辨证论治原则指导下，采用内服中药，并结合针灸、按摩、穴位贴敷手段等进行治疗确有优势【sup】[2]【/sup】 ......
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