未分化骨髓基质干细胞体外抑制淋巴细胞增殖反应的初步研究(3)
第1页 |
第4页 |
参见附件(4978KB,7页)。
本研究结果证明,BMSCs具有低免疫原性,同时具有一定的调节免疫反应的能力,可抑制混合淋巴细胞的体外增殖反应。进一步的研究将集中于BMSCs调节免疫反应的作用机制,以及使用BMSCs进行同种异体移植的动物实验,观察其能否成为细胞移植治疗中新的细胞来源。
参考文献
[1] Pittenger MF,Mackay AM,Beck SC,et al. Multilineage potential of adult human mesenchymal stem cells[J].Science,1999,284(5411):143-147.
[2] 沈海刚,张鸿坤,李晔,等.犬自体骨髓干细胞在缺血肢体中新生血管形成中的作用[J].中国中西医结合外科杂志,2008,14(4):402-406.
[3] Bruder SP,Jaiswal N,Haynesworth SE.Growth kinetics,self-renewal,and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation[J].J Cell Biochem,1997,64(2):278-294.
[4] Le Blanc K,Tammik L,Sundberg B,et al. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex[J].Scand J Immunol,2003,57(1):11-20.
[5] Tse WT,Pendleton JD,Beyer WM,et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation[J].Transplantation,2003,75(3):389-397.
[6] Karlsson H,Samarasinghe S,Ball LM,et al. Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses[J] ......
您现在查看是摘要介绍页,详见PDF附件(4978KB,7页)。