安脑平冲汤对脑出血大鼠胃泌素\生长抑素表达的影响(1)
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安脑平冲汤对脑出血大鼠胃泌素、生长抑素表达的影响
周德生【sup】1【/sup】，朱婷【sup】1【/sup】，张熙【sup】2【/sup】，胡华【sup】1【/sup】，高晓峰【sup】1【/sup】，陈晖【sup】1【/sup】
(1.湖南中医药大学第一附属医院神经内科，湖南 长沙 410007；2.湖南中医药大学病理教研室，湖南 长沙 410007)
摘 要：目的：通过观察安脑平冲汤对大鼠脑出血后血清中胃泌素(gastrin)和生长抑素(Somatostatin)表达的影响，探讨安脑平冲汤对脑出血后引发急性胃粘膜病变的防治作用。方法：将120只SD大鼠随机分为假手术组、模型组、安脑平冲汤组、雷尼替丁组。模型组、安脑平冲汤组、雷尼替丁组组内又分为24h、48h、3天、5天、7天共5个时间点，在脑立体定位仪下采用Ⅳ型胶原酶制备大鼠脑出血模型，观察大鼠脑出血后胃粘膜的病理变化，Elisa法检测血清中GAS、SS的表达。结果：与模型组比较，安脑平冲汤组和雷尼替丁组胃粘膜损伤程度降低(P<0.05)；安脑平冲汤组、雷尼替丁组胃泌素水平较模型组均有明显下降(P<0.05)；安脑平冲汤组生长抑素水平较模型组和雷尼替丁组均有明显升高(P<0.05)。结论：安脑平冲汤可能通过抑制胃泌素的表达，促进生长抑素的表达而发挥减轻脑出血后急性胃粘膜损伤的作用。
关键词：脑出血；安脑平冲汤；急性胃粘膜病变；GASSS
中图分类号：R285 文献标识码：A 文章编号：1673-7717(2011)04-0795-04
Abstract:Objective:To study the effect of Annaopingchong Decoction on the expression of serum gastrin and somatostatin in intracerebral hemorrhage rat, To discussion preventive and therapeutic effects on Annaopingchong Decoction treatment acute gastric mucosal lesion in intracerebral hemorrhage rat.Method: 120 SD rats were randomly divided into 4 group:Sham-operated group，Model group, Treatment group with Annaopingchong Decoction, Ranitidine group. They were prepared at 24h, 48h, 3d, 5d and 7d, respectively after operation, The models were established by injecting collagenase type Ⅳ stereotaxicall. the pathological changes of gastric mucosal were observed on Intracerebral hemorrhage in rats, The expression of Serum GAS, SS were analyzed by Elisa.Results:Compared with model group,The degree of gastric mucosal injury was lower in Treatment group with Annaopingchong Decoction and Ranitidine group (P<0.05) Compared with model group, The level of Gastrin was decreased in Annaopingchong Decoction group and Ranitidine group (P<0.05)Compared with model group and Ranitidine group, The level of Somatostatin in Annaopingchong Decoction group was increased(P<0.05).Conclusion:Annaopingchong Decoction can affect the expression of gastrin and somatostatin, Reduce the acute gastric mucosal injury after cerebral hemorrhage.
Key words:Cerebral Hemorrhage Annaopingchong Decoction Acute gastric mucosal lesion Gastrin Somatostatin
急性胃黏膜病变是急性脑卒中的一个严重并发症，常与脑卒中的严重程度有关，脑卒中病情越危重，急性胃黏膜损伤出血发病率就越高，程度也越重，在临床处理上有一定困难，合并有消化道出血的患者预后亦差，病死率可达半数以上。胃黏膜攻击因子和保护因子失衡是急性胃黏膜病变发病的重要机制，许多临床研究表明在急性脑出血时生长抑素和胃泌素的表达与急性胃黏膜损伤有关。因此探讨脑出血后急性胃黏膜损伤的防治措施在临床上有重要意义 ......
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