牡丹皮饮片水提取浸膏对大鼠高脂性脂肪肝的干预作用(1)
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摘 要：目的：观察牡丹皮饮片水提取浸膏(CMPAE)对大鼠高脂性脂肪肝的药效学影响。方法：建立大鼠高脂性脂肪肝模型，同时采用灌胃给药，观察CMPAE对其血清脂质、肝功能、肝脏脂质以及氧化、抗氧化损伤指标的变化，并对肝脏组织进行病理学检查。结果：含生药量0.25g·mL【sup】-1【/sup】、0.5g·mL【sup】-1【/sup】和1g·mL【sup】-1【/sup】的CMPAE可明显降低高脂性脂肪肝大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)水平；同时观察到高脂性脂肪肝大鼠肝脏组织中TC、TG水平和丙二醛(MDA)含量明显下降，而超氧化物歧化酶(SOD)活性显著增高；肝脏组织病理学改变也在一定程度上得到了减轻。结论：CMPAE可明显抑制大鼠高脂性脂肪肝的形成，其作用机制可能与调节脂质代谢，抗氧化损伤有关。
关键词：牡丹皮；高脂性脂肪肝；大鼠
中图分类号：R285.5 文献标识码：A 文章编号：1673-7717(2011)04-0896-03
Intervention effects of Cortex Moutan pieces aqueous extract on
hyperlipidemic fatty liver in rats
LI Xiang-yang【sup】1,2【/sup】,GONG Qi-hai【sup】2【/sup】,WU Qin【sup】2【/sup】, ZHANG Huan-ying【sup】1【/sup】,LI Zhi-yi【sup】1【/sup】,SHI Jing-shan【sup】2【/sup】
(1.Department of Pharmacology，Shangqiu Medical School，Shangqiu 476005, Henan,China；
2.Department of Pharmacology，Zunyi Medical School，The key Laboratory of Basic Pharmacology of
Guizhou Province，Zunyi 563003,Guizhou,China)
Abstract:Objective: To investigate the pharmacodynamic effects of CMPAE on hyperlipidemic fatty liver in rats.Methods: Rat model of hyperlipidemic fatty liver was established, while the experimental rats were gavaged CMPAE.The changes of serum lipids, liver function, liver lipid and oxidation, anti-oxidative stress indicators were observed, and liver tissue was given pathological examination.Results: The levels of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT),aspartate aminotransferase (AST) were significantly reduced in hyperlipidemic fatty liver rats by given CMPAE (which contains crude drug) at doses of 0. 25g·mL【sup】-1【/sup】, 0.5g·mL【sup】-1 【/sup】and 1g·mL【sup】-1【/sup】.We also observed that the levels of liver tissue TC, TG and maleic dialdehyde (MDA)content were significantly decreased, while superoxide dismutase (SOD) activity was significantly increasedchanges of liver histopathological has been abatementted.Conclusion: CMPAE could significantly inhibit the formation of hyperlipidemic fatty liver in rats, its mechanism may be related to regulating lipid metabolism and anti-oxidative damage ......
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