清热利湿法治疗湿热痹阻型强直性脊柱炎疗效评价(1)
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摘 要：目的：观察清热利湿法治疗湿热痹阻型强直性脊柱炎的临床疗效。方法：将68例患者随机分为治疗组和对照组，治疗组采用清热利湿的中药协定方，对照组采用缓解病情的西药。疗程为2个月。治疗前后评价强脊疾病活动指数(BASDAI)、疾病功能指数(BASFI)、晨僵时间、血沉(ESR)、C-反应蛋白(CRP)、血尿常规、肝肾功能、大便隐血。结果：治疗后两组各项指标和疗前相比均有显著性差异(P<0.05或P<0.01)；组间对比，两组患者综合疗效比较无显著性差异(P>0.05)，而不良反应发生情况明显优于对照组(P<0.05)。结论：清热利湿法对强直性脊柱炎有较好的疗效，且安全可靠。
关键词：脊柱炎；强直性；痹证；清热利湿；湿热痹阻证；疗效评价
中图分类号：R593.23 文献标识码：B 文章编号：1673-7717(2012)01-0217-03
Curative Effect Assessment of Qingrelishi Method on Ankylosing Spondylitis in Syndrome of Retention of Damp-heat
ZHOU Yi，MAO Dandan，LIU Shijue
(The Second Affiliated Hospital of Wenzhou Medical College，Wenzhou 325027，Zhejiang，China)
Abstract:Objective:To observe the clinical effect of Qingrelishi method on ankylosing spondylitis of syndrome of retention of damp-heat. Method:68 cases was randomly divided into treatment group and control group, Qingrelishi Formula were taken in the treatment group and the western medicine relieving the symptom of AS was taken in the control group, 2 mouths was a course. The following indicators were used to detect before and after treatment: BASDAI score, BASFI score, time of morning stiffness, ESR,C-reactive protein, the regular test of blood and urine, the test of liver and kidney function, blood of feces. Result:The both groups after treatment compared with pre-treatment significantly improved in indicators and the difference is statistically significant(P<0.05 or P<0.01).The total effect of both treatment group and the control group is not statistically significant(P>0.05).Improvement in adverse effects of the treatment group are better than those of the control group(P<0.05). Conclusion:Qingrelishi method can increase the efficacy of therapy for AS, which is safe and reliable.
Key words:Spondylitis，ankylosing；Arthralgia symdrome；Qingrelishi；syndrome of retention of damp-heat；Curative effect assessment
强直性脊柱炎(Ankylosing spondylitis，AS)是一种以中轴关节和肌腱韧带骨附着点的慢性炎症为主的全身性疾病，以炎性腰痛、肌腱端炎、外周关节炎和关节外表现为特点，病情发展可发生脊柱畸形和关节强直。本病病因迄今未明,病情顽固,呈进行性进展。治疗上西药多采用非甾体类抗炎药、慢作用药、糖皮质激素以及新型的生物制剂，不良反应大且仍有较多患者病情反复。为探讨中医药治疗该病的临床效果，我们将2006年8月-2010年8月收治的68例中医辨证为湿热痹阻型为主的AS患者随机分为两组，观察组采用清热利湿的中药治疗，对照组采用西药常规治疗，对两组疗效进行了对照观察，现将观察结果总结报道如下。
1临床资料
1.1入选标准①符合美国风湿病学会1984年的修订纽约标准者；②符合强直性脊柱炎中医湿热痹阻型证候标准[1]者。
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