中医药干预在女性不孕症促排卵治疗中的优势探析(1)
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摘要：目的：探讨中医药干预在女性不孕症促排卵治疗中的优势。方法：108例多囊卵巢综合征、子宫内膜异位症、盆腔炎不孕患者400个月经周期，常规运用西药HCG促排卵治疗，联合口服中药汤剂、中药外敷、针灸干预治疗，观察其排卵率、临床妊娠率、LUFS发生率、OHSS发生率、异位妊娠率、多胎率。结果：108例400个周期排卵率86.75%，临床妊娠率81.48%，LUFS发生率13.25%，OHSS发生率7.25%，异位妊娠率4.63%，多胎发生率7.95%，与文献报道单纯用HCG诱发排卵有显著性差异。结论：中医药干预在女性不孕症促排卵治疗中具有明显特色和优势，值得发掘整理、推广应用。
关键词：中医药；不孕症；促排卵；优势
中图分类号：R271.14文献标识码：B文章编号：1673-7717(2012)03-0467-02
Investigating Advantages of TCM Intervention for Inducting Ovulation in Infertile Women
XU Xiaofeng1,GU Ying2,GU Ling2,ZHU Yunpu2
(1.The TCM Hospital of Suzhou,Suzhou 215003,China;
2.Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu, China)
Abstract:Objective：To investigate the advantage that TCM intervention inducting ovulation in infertile women.Method：108 patients with polycystic ovary syndrome, endometriosis and pelvic inflammatory disease included 400 menstrual cycle. The control group were given Western medicine to induct ovulation,the othe groups were combined with herb taken orally,external herb and acupuncture separately. And then observe the ovulation rate, clinical pregnancy rate, the incidence of LUFS,OHSS,ectopic pregnancy and multiple pregnancy.Results：The ovulation rate was 86.75%, clinical pregnancy rate was 81.48%,the incidence of LUFS was 13.25%, incidence of OHSS was 7.25%, ectopic pregnancy rate was 4.63%, multiple pregnancy rate was 7.95%. There was a significant difference from the reported literature that using HCG simply.Conclusion：TCM intervention inducting ovulation has significant feature and advantage in infertile women.It is worth exploring,arrangement and application.
Key words:TCM; infertility; inducting; ovulation; advantages
收稿日期：2011-10-21
作者简介：许小凤(1963-)，女，江苏苏州人，主任中医师、教授，博士研究生导师，医学博士，研究方向：中医、中西医结合生殖内分泌。随着社会的发展，文化观念、生活环境、工作节奏等的改变，使女性不孕症的发病率呈逐年上升趋势，其中因多囊卵巢综合征(PCOS)、子宫内膜异位症(EMS)、盆腔炎(PID)等引发的卵泡发育障碍或排卵障碍是构成女性不孕的重要原因之一(约占50%～70%)。目前使用氯米芬(CC)、来曲唑(LE)、尿促性素(HMG)、促性腺激素释放激素(GnRH)、绒促性素(HCG)等药物促进卵泡发育、成熟和排卵是临床治疗排卵障碍性不孕症的主要方法。但由于PCOS、EMS、PID等疾病本身或促排卵药物引发的卵泡黄素化未破裂综合征(LUFS)、卵巢过度刺激综合征(OHSS)、多胎妊娠等困惑着临床治疗。鉴于此，本研究试图从祖国医药入手，运用口服中药促排卵汤剂、中药外敷、针灸等干预措施，联合HCG常规促排卵治疗，探讨出安全、有效、简便的促排卵干预方法，提高女性不孕症治疗中的排卵率和妊娠率，减少促排卵药物引发的副作用和医源性疾病，彰显中医药治疗女性不孕症的特色和优势 ......
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