抗疲劳中药对小鼠抗疲劳及调节免疫作用的研究(1)
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摘要：目的：探讨益气健脾、补肾调理复方中药对小鼠抗疲劳能力和免疫调节的作用。方法：6 周龄清洁级昆明种小鼠随机分为4 组：生理盐水组对照组、抗疲劳中药复方高、中、低剂量组，小鼠进行适应性运动训练 1 周，进行动物实验，每日灌胃1 次, 用药 2 周，通过爬竿试验、游泳试验、吞噬指数、免疫器官质量法( 胸腺指数和脾脏指数) 观察益气健脾、补肾调理中药复方抗疲劳的作用和增强免疫功能的作用。结果：抗疲劳中药复方能延长小鼠负重游泳的时间、延长爬竿时间，尤其是高剂量抗疲劳中药复方组能明显延长小鼠负重游泳持续时间，与生理盐水组比较有显著性差异，( P<0.05)；抗疲劳中药复方能增强巨噬细胞吞噬功能、脾脏指数(P<0.05)。结论：抗疲劳中药复方具有增强小鼠抗疲劳能力和免疫功能作用。
关键词：中药复方；吞噬指数；胸腺指数；脾脏指数；抗疲劳
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2012)03-0493-02
Effects of Herbs Compound on Immunity Function and Anti- tiredness in Mice
CHEN Liping,WU Zhengjun,TONG Zhanqi,QIAN Yan,DUAN Dongmei，ZANG Qian
(Department of Traditional Chinese Medicine,General Hospital of PLA,Beijing 100853,China)
Abstract:Objective:To investigate the effects of herbs compound on immunity function and anti - tiredness in mice.Method:Healthy mice aged 6 weeks were randomly divided into 4 groups, that is:0.9% NS control group,herbs compound decoction high, middle and low dosage group. In order to observe the effects of herbs compound on anti- tiredness and immunity function, after treating 2 weeks and adaptive training for 1 week, the indexes of the pole test, loading swimming test, and phagocytes' index, and immune organs weight (spleen index and the thymus index) were detected. Result:The herbs compound could increase the continual loading swimming and climbing time markedly, and the difference between higher dose group and NS group was significantly increased (P<0.05). Compared with NS group, higher dose herbs group also could enhance mouse clearance capacity index and improve the spleen index (P<0.05).Conclusion:The higher dose group herbs compound has obvious effects on enhancing the mouse abilities on anti- tiredness and improving the mouse immune function.
Key words:herbs compound; phagocytes' index; spleen index; thymus index; anti- tiredness;mice
收稿日期：2011-10-15
基金项目：国家科技支撑计划资助项目(2009BAI86B04)
作者简介：陈利平(1964-)，男，湖北仙桃人，副主任医师，硕士研究生导师，医学博士，研究方向：中医治疗老年病。疲劳( fatigue) 是一个涉及许多生理生化因素的综合性的生理过程, 是人体脑力或体力劳动到一定阶段时必然出现的一种正常的生理现象, 在现代社会是重要致病因素, 是一种应激表现[1]。随着社会的发展，高效率的工作、快节奏的生活，以及竞争意识的增强，人们的体力、脑力长期处于紧张状态，慢性疲劳综合征(CFS)的发病率也呈逐年上升的趋势[2]，这导致临床上以疲劳为主诉的病人日趋增多。中医药因擅长对人体进行整体调理，综合调整人体免疫机能，平衡机体阴阳气血内环境，促进人体阴阳平衡、气血调和，在治疗慢性疲劳综合征方面有其独特优势[3] ......
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