胃乐煎对HP感染模型大鼠胃病理组织的影响(1)
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摘要：目的：观察胃乐煎对HP感染模型大鼠胃病理组织的影响。方法：大鼠在去氧胆酸钠法造模基础上，灌胃丽珠维三联，清除大鼠胃內杂菌，再经口灌幽门螺杆菌(HP)复制HP感染模型，模型大鼠随机分组，观察胃乐煎对HP模型大鼠胃组织黏膜炎症指标、胃腺体厚度、腺体数量、壁细胞及主细胞的情况。结果：胃乐煎对HP模型大鼠体重有明显增加(P<0.05～0.01)；对HP模型大鼠胃腺体数目、腺体厚度、主细胞数目均有明显增加(P<0.05～0.001)；对HP模型大鼠胃组织炎症指标有显著降低作用(P<0.001)。结论：胃乐煎对HP模型大鼠胃组织有明显的改善作用。
关键词：Wistar大鼠； HP感染模型； 胃乐煎； 胃病理组织
中图分类号：R285.5文献标识码：A文章编号：1673-7717(2012)03-0551-03
Effect of Weilejian on Pathology in Gastric of Rats with Helicobacter Pylori
Associated Chronic Atrophic Gastritis
DAI Guanhai，TONG Yeling，ZHANG Chunli，YANG Min，LU Zheng, YANG Feng
(Institute of Basic Medicine, Zhejiang Academy of TCM, Hangzhou 310007, Zhejiang,China)
Abstract:Objective: To observe the effect of Weilejian on pathology in gastric of rats with Helicobacter pylori(Sydney Strain 1,ss1) associated chronic atrophic gastritis(CAG). Methods: HP associated chronic atrophic gastritis models were induced (Rats were treated with sodium deoxycholate ,then fed-J yuansuan Bijia Pian for clear rat stomach bacteria, And cultured HP(ss1) were orally administered). HP associated CAG rats were randomly divided into the groups treated with Weilejian with different doses. Inflammatory reaction, the thickness and the number of gastric glands, the number of parietal cells and chief cells in rat gastric mucosa were observed. Results: Weilejian can significantly increase body weight(P<0.05～0.01), can significantly increase the number of gastric glands, the glands thickness, the number of primary cells(P<0.05～0.001) and significantly reduce the indicators of gastric inflammation(P<0.001) for HP associated CAG. Conclusion: Weilejian can significantly improve the rat gastric tissue for HP associated CAG.
Key words:wistar rats；HP associated CAG；weilejian；pathology in gastric
胃乐煎是国家级名老中医陆拯主任中医师多年从事脾胃病的经验方基础上增加蜂胶研制成，对胃脘痛、胃痞等具有显著疗效。现代药理学研究证明，蜂胶具有免疫增强作用、抗氧化作用、抗溃疡作用和抗菌消炎作用[1]。因此我们用该方对HP感染模型大鼠进行实验观察，为临床上胃乐煎治疗HP感染提供实验依据。
1实验材料
1.1实验药物胃乐煎片：棕色颗粒，主要由蜂胶、鸡矢藤、吴茱萸、炒白术、黄连、枳壳等组成，每片重量0.47g，含2.107g生药，临床用量为每人12片/日，60片/瓶，批号：100401，每片含黄连(以盐酸小檗碱C20H17NO4·HCl计)为3.86mg，含枳壳(以柚皮苷C27H32O14)为9.02mg，由上海交大穗轮药业有限公司提供(我院委托加工) ......
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