麝香保心丸对老年冠心病合并糖尿病患者大动脉弹性的影响(1)
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摘要：目的：探讨麝香保心丸对老年冠心病合并糖尿病患者大动脉弹性的影响。方法：选取148例老年冠心病合并糖尿病患者，随机分为实验组72例和对照组76例，实验组在常规药物治疗基础上加服麝香保心丸，对照组仅予常规药物治疗，观察治疗前和治疗12周后大动脉弹性(ABI、CAVI)及总胆固醇(TC)、低密度脂蛋白(LDL-C)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)等指标。 结果：实验组患者治疗后ABI、CAVI较治疗前显著改善，差异有统计学意义(P<0.05)，对照组治疗后ABI、CAVI较治疗前有改善倾向，但差异无统计学意义(P>0.05)。治疗后两组患者TC、LDL-C、FBG、HbA1c、hs-CRP、FIB均较治疗前下降，差异有统计学意义(P<0.05)；实验组hs-CRP、FIB较对照组下降更显著，差异有统计学意义(P<0.05)，而两组TC、LDL-C、FBG、HbA1c比较差异无统计学意义(P>0.05)。结论：麝香保心丸可以改善老年冠心病合并糖尿病患者的大动脉弹性，麝香保心丸对炎症反应有抑制作用，在抗动脉粥样硬化方面有一定的协同作用，这对减少老年冠心病合并糖尿病患者的并发症有重要意义。
关键词：麝香保心丸；冠心病；糖尿病；动脉弹性
中图分类号：R543.12文献标识码：B文章编号：1673-7717(2012)03-0567-03
Effects of Shexiang Baoxin Pill on Artery Elasticity in Elderly Patients with
Coronary Heart Disease and Diabetes
SHOU Xiaoling, REN Aihua, WANG Bozhong, ZHU Liyue
(Department of Cardiac Rehabilitation, Zhejiang Hospital, Hangzhou 310013,Zhejiang，China)
Abstract: Objective：To investigate the effects of Shexiang Baoxin Pill on artery elasticity in elderly patients with coronary heart disease and diabetes. Methods：148 elderly patients with coronary heart disease and diabetes were randomly divided into experimental group(n=72) and control group (n=76).The experimental group received Shexiang Baoxin Pill based on the conventional drug therapy, and the control group only received conventional drug treatment. The artery elasticity (ABI, CAVI) and total cholesterol (TC), low density lipoprotein (LDL-C), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), high-sensitivity C-reactive protein (hs-CRP ), fibrinogen (FIB) were measured before and 12 weeks after treatment. Results：The ABI and CAVI in experimental group were significantly improved compared those before treatment, and the difference was statistically significant (P<0.05). The ABI and CAVI in the control group became better than those before treatment, but the difference was not statistically significant (P> 0.05 ). After treatment, the TC, LDL-C, FBG, HbA1c, hs-CRP, FIB levels decreased compared to that before treatment in both experimental and control groups, and the difference was statistically significant (P<0 ......
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