长期小剂量鼻渊舒胶囊治疗慢性鼻-鼻窦炎疗效分析(1)
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摘 要：目的：观察分析长期小剂量中成药鼻渊舒胶囊治疗慢性鼻-鼻窦炎(CRS)的疗效。方法：将不伴息肉的CRS患者依就诊时间顺序随机分为鼻渊舒组和对照组。鼻渊舒组24例患者口服鼻渊舒胶囊0.9g(0.3g/粒)，1次/天(前2周3次/天；接下来的2周2次/天)，使用12周；对照组24例患者口服克拉霉素片0.25g，1次/天(前2周为2次/天)，使用12周。治疗前后采用视觉模拟量表(visual analogres scale, VAS)和Lund-Mackey鼻窦CT评分对患者疗效进行主、客观评估。结果：鼻渊舒组治疗后VAS、鼻窦CT平均得分为4.42±1.53和5.68±2.43，显著低于治疗前7.42±1.09和8.92±2.64，治疗前后比较差异均有统计学意义(P<0.01)；克拉霉素组治疗后VAS、鼻窦CT平均得分为3.54±1.84和3.75±2.59，显著低于治疗前7.42±1.09和8.92±2.64，差异均有统计学意义(P<0.01)。治疗后鼻渊舒组与克拉霉素组比较，两组VAS评分差异无统计学意义(t =1.789，P>0.05)，而两组鼻窦CT评分差异有统计学意义(t =2.527，P<0.05)。 结论：12周小剂量的中成药鼻渊舒胶囊治疗CRS有效，但该药在鼻窦CT影像学评估的改善程度上不及小剂量大环内酯类药物克拉霉素。
关键词：鼻渊舒；克拉霉素；鼻窦炎；长期小剂量疗法
中图分类号：R765.41
文献标识码：A
文章编号：1673-7717(2012)04-0822-04
Effect Evaluation of Biyuanshu Capsule Treating Chronic Rhinosinusitis
with Long Course and Low Dosage
LIU Ju-bo，LI Xian-hua，ZHANG Jun-zhong，TAN Yi，LU Xiang，LIU Li-ya，LI Qiang，YANG Xiao-xia，FENG Zhi-jian，HONG Yi-chun
(First Rongjun Hospital of Guangdong，Guangzhou 510260，Guangdong，China)
Abstract:Objective：To observe the clinical treatment effect of Biyuanshu Capsule on treating chronic rhinosinusitis(CRS).Methods：48 patients with CRS were randomly assigned into two groups. 24 patients in Biyuanshu group were administered Biyuanshu capsule 0.9g once a day(0.9g t.i.d in first 2 weeks and 0.9g b.i.d in following 2 weeks)for 12 weeks. 24 patients in control group were administered clarithromycin tablet 0.25g once a day(0.25g b.i.d in first 2 weeks was)for 12 weeks. The effect was evaluated by visual analogres scale(VAS)and Lund-Macksy CT mark system.Results：The VAS and CT image mark significantly decreased to 4.42±1.53 and 5.68±2.43(P<0.01)in the Biyuanshu group while 3.54±1.84 and 3.75±2.59(P<0.01)in the control group after treatment.There was no significant difference of the VAS(t=1.789，P>0.05)between the two groups，while there was significant difference of CT image mark(t=2.527，P<0.05)between the two groups.Conclusion：Long-term use of low dosage Biyuanshu Capsule treating CRS has effect. Biyuanshu Capsule was not as good as clarithromycin on improving the CT image after the treatment.
Key words:Biyuanshu；clarithromycin；sinusitis；chronic；longer course and lower dosage therapy ......
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