葛根素治疗四肢外伤性肿胀的临床疗效观察(1)
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摘 要：目的：评价葛根素治疗四肢外伤性肿胀的临床疗效。方法：在合适患者中选择58例作为治疗组，66例作为空白组，治疗组使用注射用葛根素400mg加入0.9%氯化钠注射液250mL中静滴，2h滴完，1日1次，10天为1个疗程；空白组除不加注射用葛根素外其余与治疗组完全一致。结果：治疗组和空白组四肢外伤性肿胀前后症状评分变化有明显差异(P<0.01)；治疗组肿胀前后评分差值变化和空白组相比有明显差异(P<0.05)；在临床疗效中，治疗组总有效率达96.55%，空白组总有效率为68.18%。总的各项指标治疗组均优于空白组。结论：注射用葛根素应用于四肢外伤性肿胀的治疗具有良好的意义。
关键词：葛根素；四肢；外伤性肿胀
中图分类号：R285.6
文献标识码：B
文章编号：1673-7717(2012)04-0840-02
Clinical Observation on Efficacy of Puerarin Treating Traumatic Four Limb Swelling
CHEN Jing-bai, ZHOU Zhong-dong, LI Yao-wang, XIE Hao-yang
(Shaoxing City Hospital of TCM, Shaoxing 312000，Zhejiang, China)
Abstract:Objective: To value clinical efficacy of puerarin on traumatic four limb swelling. Methods: 124 cases accordance with inclusion criteria were randomly assigned into treatment group(n=58) and control group(n=66). In the treatment group, puerarin injection 400mg in 0.9% NS 250mL was given daily by intravenous drip (in 2hours) once a day. While the patients in the control group received the same treatment as the treatment group without application of puerarin injection. Results: Obvious difference in score of swelling of traumatic four limb swelling was found between the two groups after treatment (P<0.01). The differential value of score for swelling was significant in the treatment group after treatment compared with the control group (P<0.05). As for clinical efficacy, the total effective rate in the treatment group is 96.55%, the control group is 68.18%. In short, All indexes in the treatment group were better than that in the control group. Conclusion: It is highly valuable that injection of puerarin is used to treat traumatic four limb swelling.
Key words:puerarin; four limb; traumatic swelling
葛根素系从豆科植物野葛或甘葛藤根中提取的一种黄酮苷，为血管扩张药，有扩张冠状动脉和脑血管、降低心肌耗氧量、改善微循环和抗血小板聚集的作用。四肢外伤为外科的常见病，外伤时常伴有肿胀而致使病人感受痛苦。迅速改善患者的肿胀状况既可减轻患者的痛苦，又有利于病人遵从医嘱。根据葛根素的药理作用,我们尝试用葛根素治疗四肢外伤性肿胀，取得良好疗效，现报道如下。
1 资料与方法
1.1 病例选择
选择124例住院患者，按中华全国中医学会脉管专业委员会1990年制定的诊断标准选择因四肢外伤引起肿胀，伤后入院不超过24h的病人，于入院时随机分为治疗组和空白组。若住院不足10天或在此期间选用了其他可能影响血液流变学的药物如血小板抑制剂或抗凝药物的患者和住院过程中选择手术的患者，以及四肢中两侧肢均肿胀的患者将被排除在观察组外。两组间病人年龄、性别、体重等无明显差异。其中治疗组58例、空白组66例。
1.2 治疗方法
治疗组用注射用葛根素(北京四环科宝制药有限公司生产， 200mg/支)400mg加入0.9%氯化钠注射液250mL中静滴 ......
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