糖蛋白抗原125水平对子宫体癌的预测价值(1)
【摘要】目的：探讨糖蛋白抗原(CA)125水平对子宫体癌的预测价值。方法：回顾性分析术前CA125水平与子宫体癌的病理组织分级、宫壁肌层浸润深度、宫外淋巴血管受累范围、淋巴结状况和临床分期之间的关系。结果：CA125水平升高与子宫体癌晚期(P<0.001)和淋巴结状况(是否浸润)有关，也与子宫肌层浸润深度、肿瘤病理组织分级有关。接受器操作特性(ROC)曲线显示子宫体癌浸润的深度、宫外淋巴血管受累范围及肿瘤病理组织分级等在预测晚期子宫体癌的准确度分别为73%、77%和80%。然而，CA125水平预测晚期子宫体癌的准确度可高达94%，将CA125临界值定为35 kU/L时，其敏感度和特异性分别为95%和90%，阴性预测值为97%，阳性预测值为78%。结论：CA125可作为子宫体癌淋巴转移和宫外蔓延扩散的一种重要预测指标。
【关键词】糖蛋白抗原125；子宫体癌；预测价值
文章编号：1009-5519(2007)11-1765-03 中图分类号：R446 文献标识码：A
The value of CA125 level for the prediction of uterine corpus carcinoma
FANG Rui-fang,LIN Qing-shun,LIN Mei-ling
(Department of Clinical Laboratories,The People's Hospital of Huilai,Guangdong 515200,China)
【Abstract】Objective:To evaluate the value of CA125 level for the prediction of uterine corpus carcinoma.Methods:We conducted a retrospective analysis of the correlation of preoperative CA125 level with the histopathological grading of uterine corpus carcinoma,depth of infiltration,lymph vascular space involvement(LVSI),lymph node(LN) status and age.Results:High CA125 level was correlated with advanced stage of uterine corpus carcinoma(P50%者，CA125均值为(202.97±62.43)KU/L。CA125水平与宫外淋巴血管受累范围的关系：宫外淋巴血管阳性者，CA125均值为(71.43±23.94)KU/L，宫外淋巴血管阴性者，CA125均值为(291.6±91.38)KU/L。
[ 下 页 ], 百拇医药(方瑞芳 林庆顺 林美玲)
【关键词】糖蛋白抗原125；子宫体癌；预测价值
文章编号：1009-5519(2007)11-1765-03 中图分类号：R446 文献标识码：A
The value of CA125 level for the prediction of uterine corpus carcinoma
FANG Rui-fang,LIN Qing-shun,LIN Mei-ling
(Department of Clinical Laboratories,The People's Hospital of Huilai,Guangdong 515200,China)
【Abstract】Objective:To evaluate the value of CA125 level for the prediction of uterine corpus carcinoma.Methods:We conducted a retrospective analysis of the correlation of preoperative CA125 level with the histopathological grading of uterine corpus carcinoma,depth of infiltration,lymph vascular space involvement(LVSI),lymph node(LN) status and age.Results:High CA125 level was correlated with advanced stage of uterine corpus carcinoma(P50%者，CA125均值为(202.97±62.43)KU/L。CA125水平与宫外淋巴血管受累范围的关系：宫外淋巴血管阳性者，CA125均值为(71.43±23.94)KU/L，宫外淋巴血管阴性者，CA125均值为(291.6±91.38)KU/L。
[ 下 页 ], 百拇医药(方瑞芳 林庆顺 林美玲)