头皮屑中几种细胞因子的表达及其意义(1)
【摘要】目的:研究头皮糠疹、头皮脂溢性皮炎、头皮银屑病与正常人的头皮屑,比较各组间的白介素-1α、白介素-1β、白介素-1受体拮抗剂和白介素-8的变化,为头皮屑相关疾病的炎症发病机制提供客观依据。方法:收集25例头皮糠疹组,32例脂溢性皮炎组,25例头皮银屑病组以及25例正常对照组,通过Sebutape胶带粘贴收集头皮屑,经超声降解,应用ELISA方法测定头皮屑萃取液中的细胞因子和BCA增强法检测其中总蛋白的含量。结果:白介素-1α/总蛋白(IL-1α/TP)在头皮糠疹组高于正常对照组(P0.05);4组之间的白介素-1β/总蛋白(IL-1β/TP)统计结果无差异;白介素-1受体拮抗剂/总蛋白(IL-1ra/TP)在脂溢性皮炎组比正常对照组有升高(P>0.05),头皮银屑病组中含量显著高于正常对照组(P0.05).There was not significantly different in the value of interleukin-1β/total protein(IL-1β/TP) among 4 groups.The value of interleukin-1 receptor antagonist/total protein(IL-Ira/TP) in the seborrheic dermatitis group was higher than that in the control group(P=0.059),which in the scalp psoriasis group was significantly higher than that in the control group(P
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