Yasar等[21]的研究揭示了单纯冠状动脉扩张的病人与具有正常冠状动脉的对照组相比，PF4水平明显升高。无论是冠状动脉痉挛或扩张都会对冠状动脉内皮造成损伤，导致血小板聚集、活化，释放PF4等反映血小板活化的分子标志物，使PF4升高。

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