内质网应激在2型糖尿病发病及治疗中的作用(3)
[13] Laybutt DR，Preston AM，Akerfeldt MC，et al.Endoplasmic reticu-lum stress contributes to beta cell apoptosis in type 2 diabetes[J].Diabetologia 2007;50(4):752.
[14] Itani SI，Ruderman NB， Schmieder F，et al.Lipid-induced insulin resistance in human muscle is associated with changes in diacyl-glycerol，protein kinase C，and IkappaB-alpha[J].Diabetes， 2002，51(7):2005.
[15] Miller RS，Diaczok D，Cooke DW.Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes[J].Biochem Biophys Res Commun，2007，362(1):188.
[16] Karaskov E，Scott C，Zhang L，et al.Chronic palmitate but not oleateexposure induces endoplasmic reticulum stress ， which may con-tribute to INS-1 pancreatic beta-cell apoptosis[J]. Endocrinology，2006，147(7):3398.
[17] Oyadomari S，Koizumi A，Takeda K，et al. Targeted disruption of theChop gene delays endoplasmic reticulum stress-mediated diabetes[J].J Clin Invest，2002，109(4)：525.
[18] Ozcan U，Yilmaz E，Ozcan L，et al.Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes[J]. Science，2006，313(5790)：1137.
[19] Sreejayan N，Dong F，Kandadi MR，et al. Chromium Alleviates Gl-ucose Intolerance Insulin Resistance and Hepatic ER Stress in ObeseMice[J].Obesity (Silver Spring)，2008，16(6):1331.
收稿日期：2008-06-17, 百拇医药(冷一平 海春霞)
[14] Itani SI，Ruderman NB， Schmieder F，et al.Lipid-induced insulin resistance in human muscle is associated with changes in diacyl-glycerol，protein kinase C，and IkappaB-alpha[J].Diabetes， 2002，51(7):2005.
[15] Miller RS，Diaczok D，Cooke DW.Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes[J].Biochem Biophys Res Commun，2007，362(1):188.
[16] Karaskov E，Scott C，Zhang L，et al.Chronic palmitate but not oleateexposure induces endoplasmic reticulum stress ， which may con-tribute to INS-1 pancreatic beta-cell apoptosis[J]. Endocrinology，2006，147(7):3398.
[17] Oyadomari S，Koizumi A，Takeda K，et al. Targeted disruption of theChop gene delays endoplasmic reticulum stress-mediated diabetes[J].J Clin Invest，2002，109(4)：525.
[18] Ozcan U，Yilmaz E，Ozcan L，et al.Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes[J]. Science，2006，313(5790)：1137.
[19] Sreejayan N，Dong F，Kandadi MR，et al. Chromium Alleviates Gl-ucose Intolerance Insulin Resistance and Hepatic ER Stress in ObeseMice[J].Obesity (Silver Spring)，2008，16(6):1331.
收稿日期：2008-06-17, 百拇医药(冷一平 海春霞)