陈开兰，李维珍(贵州航天医院检验科，贵州遵义563000)

    ·论著·

    乙型肝炎肝硬化患者抗病毒治疗后HBV-DNA含量与甲状腺激素的相关性

    陈开兰，李维珍

    (贵州航天医院检验科，贵州遵义563000)

    目的探讨乙型肝炎(乙肝)肝硬化患者抗病毒治疗后乙肝病毒(HBV)-DNA含量与甲状腺激素水平的相关性。方法选取该院2013年1月至2015年6月收治的96例抗病毒治疗乙肝肝硬化患者作为病例组，选取同期该院40例健康体检者作为健康对照组。对比抗病毒治疗前病例组与对照组甲状腺激素水平、病例组治疗前后甲状腺激素水平变化、HBV-DNA转阴患者与未转阴患者甲状腺激素水平。结果抗病毒治疗前，病例组患者甲状腺激素水平显著低于健康对照组，差异有统计学意义(P<0.05)；与治疗前比较，病例组患者抗病毒治疗后三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)、游离甲状腺素(FT4)水平升高，促甲状腺激素(TSH)降低，差异均有统计学意义(P<0.05)；HBV-DNA转阴患者较未转阴患者T3、T4、FT3、FT4水平升高，TSH降低，差异均有统计学意义(P<0.05)。结论乙肝肝硬化患者抗病毒治疗后甲状腺激素水平与HBV-DNA含量有一定相关性，抗病毒治疗可以改善患者甲状腺激素失衡状态。

    肝炎，乙型；肝硬化；甲状腺激素类/血液；肝炎病毒

    【Abstract】Objective To investigate the correlation between HBV-DNA leveland thyroid hormone levelafter antiviral therapy in the patientswith hepatitis B induced cirrhosis.Methods Ninety-six cases of hepatitis B induced cirrhosis treated by antiviral therapy in our hospital from January 2013 to June 2015 were selected as the case group and contemporaneous 40 individuals undergoing the healthy physical examination were selected as the control group.The thyroid hormone levelswere compared between before antiviral therapy in the case group and the control group ......