中图分类号：R541.7 文献标 识码：A 文章编号：1009_816X(2011)04_0270_02

    DOI:10.3969/j.issn.1009_816X.2011.04.07

    The Tp_e/QT Ratio change in Chronic Heart Failure Patients and ItsClinical Significance. LU Hai_yan, SHI Zhen_hua, CHEN Li_ping, et al. Lishui Central Hospita l, Zhejiang 323000, China

    [Abstract] Objective To explore The Tp_e/QT Ratio change in Ch ronic Heart Failure Patients and Its Clinical Significance.Methods 158 patients with chronic h eart failure (CHF group) and 200 healthy adults (control group) were measured wi thin 24 hours of their admission of the first ECG QTd, Tp_e, QTc, and calculatethe Tp_e/QT ratio, and analyzed the relationship beween it and the occurrence ofthe m alignant ventricular arrhythmia.Results Compa red with the control group, Electrocardiogram in patients with heart failure.TheQTd, Tp_e and QTc were significantly prolonged [(35.58±15.86) ms vs. (56.31±33.18) ms, (88.48±13.17) ms vs (139.36±41.12) ms and (427.58±32.21 ) ms vs. (485.23±49.63) ms, P<0.01], and Tp_e/QT ratio increased signi ficantly (0.21±0.05 vs. 0.29±0.09, P<0.01). Among 158 patients withchronic heart failure, there were 34 patients (21.5%) having m alignant ventricu lar arrhythmias, and their ECG, QTd, Tp_e, and QTc were longer than those withou t m alignant ventricular arrhythmias, but the Tp_e/QT ratio increased significa ntly (0.34±0.03 vs 0.27±0.06, P<0.01). Conclusions Among the chronic he art failure patients, Tp_e/QT ratio is significantly longer than that in health y adults. Tp_e/QT ratio and the incidence of m alignant ventricular arrhythmiaare significantly correlated, and they may be the most important early warning i ndicators for the sudden cardiac death. ......