MMP_9、CD147、hs_CRP、IL_6对急性脑梗死伴微出血的诊断价值(1)
[摘要]目的探讨生物学标志物对脑微出血(CMB)的诊断价值。方法应用磁共振行常规序列及磁敏感加权成像(SWI)序列探测急性期脑梗死，选入84例患者，其中无微出血组62例、合并微出血组22例，并收集同期健康体检者40例，分别检验金属蛋白酶(MMP_9)、细胞外基质金属蛋白酶诱导剂(CD147)、超敏C反应蛋白(hs_CRP)、白介素_6(IL_6)水平并进行相关分析。结果合并微出血组生物学标志物水平明显高于无微出血组，且均高于同期健康体检组，差异有统计学意义(P<001)。Logistics回归分析显示生物学标志物水平与CMB相关，其中CD147与hs_CRP检验效能最高。结论生物学标志物MMP_9、CD147、hs_CRP、IL_6与急性期脑梗死合并微出血密切相关，具有重要的诊断价值。
[关键词]急性脑梗死；脑微出血；生物学标志物
中图分类号：R7433文献标识码：A文章编号：1009_816X(2016)02_0098_03
doi：103969/jissn1009_816x20160206The Diagnostic Values of MMP_9、CD147、hs_CRP、IL_6 for Acute Cerebral Infarction with Microbleeds. WU Shuo， ZHAO Yan_xin. Department of Neurology， ShangHai BaoShan District LuoDian’s Hospital， Shanghai 201908， China
[Abstract] Objective To discuss diagnostic values of biological markers for cerebral microbleeds (CMB). Methods Magnetic resonance (MRI) line of regular sequences and magnetic sensitive weighted imaging (SWI) sequence were used to detect acute cerebral infarction 84 patients were selected and divided into two groups： non_cerebral microbleeds group(n=62) and merging cerebral microbleeds group (n=22) 40 healthy cases of the corresponding period were collected Metalloproteinases MMP_9， CD147， hypersensitive c_reactive protein (hs_CRP) interleukin (IL_6) were respectively tested and correlation analysis between CMB and these markers was made Results Level of the biological markers in merging cerebral microbleeds group was significantly higher than in non_cerebral microbleeds group， and they were both significantly higher than that in healthy check_up group， which was statistically significant (P<001) Logistics regression analysis showed that level of specific biological markers was correlation with CMB， power of test of CD147 and hs_CRP were higher Conclusions MMP_9， CD147， hs_CRP， IL_6 are closely related to acute cerebral infarction with microbleedings， which has important diagnostic values
[Key words] Acute cerebral infarct； Cerebral microbleedings； Biological markers
急性缺血性脑卒中发病率逐年上升，是目前致残率、致死率最高的疾病之一，其主要治疗方法有抗血小板聚集、抗凝、溶栓等。但对于缺血性脑卒中伴脑微出血(cerebral microbleedings，CMB)的患者，如何在治疗中避免增加出血风险是一个值得探讨的临床问题。因此本文通过探讨血液生物标志物金属基质蛋白酶_9(Matrix Metalloproteinase_9，MMP_9)、细胞外基质金属蛋白酶诱导剂CD147(extraceular MMP inducer，EMMPRIN)，超敏C反应蛋白(HypersensitiveC_reactive protein，hs_CRP)、白细胞介素_6(IL_6)与CMB的关系，明确生物标志物对CMB的诊断价值。
1资料与方法
11一般资料：选入2013年1月至2014年7月我院神经内科急性期脑梗死患者84例，其中男59例，女25例，年龄42～73岁，平均(5521±1132)岁。所有病例诊断均符合《中国急性缺血性脑卒中诊治指南2010》的诊断标准，并均在发病72小时内经头颅MRI证实。根据是否合并CMB将选取的急性脑梗死患者分为两组：无CMB组62例，其中男45例，女17例，平均(5323±1024)岁。CMB组22例，其中男14例，女8例，平均(5715±1225)岁。同期选入健康体检者40例为对照组，其中男26例，女14例，平均(5087±1096)岁，经头颅MRI检查排除急性缺血性脑卒中诊断。所有病例均排除出血性脑卒中、肝肾及心肺功能不全、长期服用抗凝药物、贫血、恶性肿瘤、入院前1个月内患炎症性疾病、行外科手术或有重大创伤等。, 百拇医药(吴硕 赵延欣)
[关键词]急性脑梗死；脑微出血；生物学标志物
中图分类号：R7433文献标识码：A文章编号：1009_816X(2016)02_0098_03
doi：103969/jissn1009_816x20160206The Diagnostic Values of MMP_9、CD147、hs_CRP、IL_6 for Acute Cerebral Infarction with Microbleeds. WU Shuo， ZHAO Yan_xin. Department of Neurology， ShangHai BaoShan District LuoDian’s Hospital， Shanghai 201908， China
[Abstract] Objective To discuss diagnostic values of biological markers for cerebral microbleeds (CMB). Methods Magnetic resonance (MRI) line of regular sequences and magnetic sensitive weighted imaging (SWI) sequence were used to detect acute cerebral infarction 84 patients were selected and divided into two groups： non_cerebral microbleeds group(n=62) and merging cerebral microbleeds group (n=22) 40 healthy cases of the corresponding period were collected Metalloproteinases MMP_9， CD147， hypersensitive c_reactive protein (hs_CRP) interleukin (IL_6) were respectively tested and correlation analysis between CMB and these markers was made Results Level of the biological markers in merging cerebral microbleeds group was significantly higher than in non_cerebral microbleeds group， and they were both significantly higher than that in healthy check_up group， which was statistically significant (P<001) Logistics regression analysis showed that level of specific biological markers was correlation with CMB， power of test of CD147 and hs_CRP were higher Conclusions MMP_9， CD147， hs_CRP， IL_6 are closely related to acute cerebral infarction with microbleedings， which has important diagnostic values
[Key words] Acute cerebral infarct； Cerebral microbleedings； Biological markers
急性缺血性脑卒中发病率逐年上升，是目前致残率、致死率最高的疾病之一，其主要治疗方法有抗血小板聚集、抗凝、溶栓等。但对于缺血性脑卒中伴脑微出血(cerebral microbleedings，CMB)的患者，如何在治疗中避免增加出血风险是一个值得探讨的临床问题。因此本文通过探讨血液生物标志物金属基质蛋白酶_9(Matrix Metalloproteinase_9，MMP_9)、细胞外基质金属蛋白酶诱导剂CD147(extraceular MMP inducer，EMMPRIN)，超敏C反应蛋白(HypersensitiveC_reactive protein，hs_CRP)、白细胞介素_6(IL_6)与CMB的关系，明确生物标志物对CMB的诊断价值。
1资料与方法
11一般资料：选入2013年1月至2014年7月我院神经内科急性期脑梗死患者84例，其中男59例，女25例，年龄42～73岁，平均(5521±1132)岁。所有病例诊断均符合《中国急性缺血性脑卒中诊治指南2010》的诊断标准，并均在发病72小时内经头颅MRI证实。根据是否合并CMB将选取的急性脑梗死患者分为两组：无CMB组62例，其中男45例，女17例，平均(5323±1024)岁。CMB组22例，其中男14例，女8例，平均(5715±1225)岁。同期选入健康体检者40例为对照组，其中男26例，女14例，平均(5087±1096)岁，经头颅MRI检查排除急性缺血性脑卒中诊断。所有病例均排除出血性脑卒中、肝肾及心肺功能不全、长期服用抗凝药物、贫血、恶性肿瘤、入院前1个月内患炎症性疾病、行外科手术或有重大创伤等。, 百拇医药(吴硕 赵延欣)