脑血管病防治：从心脑血管病联防联治谈起(10)
[47] Powers WJ， Rabinstein AA， Ackerson T， et al. 2018 Guidelines for the early management of patients with acute ischemic stroke： a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke， 2018， 49(3)：e46-e110.
[48] Kirchhof P， Marijon E， Fabritz L， et al. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice[J]. Int J Cardiol， 2013， 166(2)：366-374.
[49] Zhang X， Chen S， Yoo S， et al. Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death[J]. Cell， 2008， 135(6)：1017-1027.
[50] Spronk HM， De Jong AM， Verheule S， et al. Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation[J]. Eur Heart J， 2017， 38(1)：38-50.
[51] Wakisaka Y， Chu Y， Miller JD， et al. Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice[J]. J Cereb Blood Flow Metab， 2010， 30(1)：56-69.
[52] Passos GF， Kilday K， Gillen DL， et al. Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis[J]. J Cereb Blood Flow Metab， 2016， 36(2)：399-404.
[53] Li H， Xu H， Wen H， et al. Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice[J]. J Cereb Blood Flow Metab， 2019， 39(3)：547-561.
[54] Chen B， Sun H， Zhao Y， et al. An 85-gene coexpression module for progression of hypertension-induced spontaneous intracerebral hemorrhage[J]. DNA Cell Biol， 2019， 38(5)：449-456.
[55] Saulnier-Blache JS， Wilson R， Klavins K， et al. Ldlr(-)(/)(-) and ApoE(-)(/)(-) mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease[J]. Atherosclerosis， 2018， 276：140-147.
[56] Van der Donckt C， Van Herck JL， Schrijvers DM， et al. Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization， plaque rupture， myocardial infarction， stroke， and sudden death[J]. Eur Heart J， 2015， 36(17)：1049-1058.
[57] Hara T， Phuong PT， Fukuda D， et al. Protease-activated receptor-2 plays a critical role in vascular inflammation and atherosclerosis in apolipoprotein e-deficient mice[J]. Circulation， 2018， 138(16)：1706-1719.
[58] Stachon P， Heidenreich A， Merz J， et al. P2X7 deficiency blocks lesional inflammasome activity and ameliorates atherosclerosis in mice[J]. Circulation， 2017， 135(25)：2524-2533., 百拇医药(陆佳楠 张建民)
[48] Kirchhof P， Marijon E， Fabritz L， et al. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice[J]. Int J Cardiol， 2013， 166(2)：366-374.
[49] Zhang X， Chen S， Yoo S， et al. Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death[J]. Cell， 2008， 135(6)：1017-1027.
[50] Spronk HM， De Jong AM， Verheule S， et al. Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation[J]. Eur Heart J， 2017， 38(1)：38-50.
[51] Wakisaka Y， Chu Y， Miller JD， et al. Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice[J]. J Cereb Blood Flow Metab， 2010， 30(1)：56-69.
[52] Passos GF， Kilday K， Gillen DL， et al. Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis[J]. J Cereb Blood Flow Metab， 2016， 36(2)：399-404.
[53] Li H， Xu H， Wen H， et al. Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice[J]. J Cereb Blood Flow Metab， 2019， 39(3)：547-561.
[54] Chen B， Sun H， Zhao Y， et al. An 85-gene coexpression module for progression of hypertension-induced spontaneous intracerebral hemorrhage[J]. DNA Cell Biol， 2019， 38(5)：449-456.
[55] Saulnier-Blache JS， Wilson R， Klavins K， et al. Ldlr(-)(/)(-) and ApoE(-)(/)(-) mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease[J]. Atherosclerosis， 2018， 276：140-147.
[56] Van der Donckt C， Van Herck JL， Schrijvers DM， et al. Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization， plaque rupture， myocardial infarction， stroke， and sudden death[J]. Eur Heart J， 2015， 36(17)：1049-1058.
[57] Hara T， Phuong PT， Fukuda D， et al. Protease-activated receptor-2 plays a critical role in vascular inflammation and atherosclerosis in apolipoprotein e-deficient mice[J]. Circulation， 2018， 138(16)：1706-1719.
[58] Stachon P， Heidenreich A， Merz J， et al. P2X7 deficiency blocks lesional inflammasome activity and ameliorates atherosclerosis in mice[J]. Circulation， 2017， 135(25)：2524-2533., 百拇医药(陆佳楠 张建民)
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