张佳阳 李红男 刘润生 曲明海 邢雪琨

    【摘要】? 肝脏缺血再灌注会引起细胞损伤和器官功能障碍。间充质干细胞外囊泡作为细胞间物质转运和信息传递的载体，在肝脏抗氧化应激、促进组织修复等方面发挥重要作用。不同来源的间充质干细胞外囊泡转运效果不同，已有的细胞和动物实验证明间充质干细胞外囊泡有助于改善肝脏缺血再灌注损伤。本文从间充质干细胞外囊泡对肝脏缺血再灌注机制的研究展开综述，探讨其发挥的重要作用。

    【关键词】? 肝脏缺血再灌注；间充质干细胞；细胞外囊泡

    中图分类号? R329.2? ? 文献标识码? A? ? 文章编号? 1671-0223(2023)01--04

    Research progress of extracellular vesicles of mesenchymal stem cells involved in hepatic ischemia-reperfusion Zhang Jiayang， Li Hongnan， Liu Runsheng， Qu Minghai， Xing Xuekun.School of Public Health， Guilin Medical University，Guilin 541199， China

    【Abstract】? Liver ischemia-reperfusion can cause cell damage and organ dysfunction. Study found that mesenchymal stem cells outside the vesicles as a material transfer and information transmission between the cells of the carrier， to promote tissue repair in liver oxidative stress resistance， play a role in such aspects， ectomesenchymal stem cells from different sources outside the vesicle transport effect is different， the existing cell and animal experiments proved vesicle helps to improve liver ischemia-reperfusion injury. It will bring a new direction to the experiments of exocyst administration of mesenchymal stem cells after liver transplantation. This article reviews the mechanism of hepatic ischemia-reperfusion induced by extracellular vesicles of mesenchymal stem cells and discusses its important role. ......