src抑制的蛋白激酶C底物调控内皮细胞分泌TNF—α(2)
【Key words】Lipopolysaccharide; Pulmonary microvascular endothelial cells; Tumor necrosis factor; Src-suppressed C kinase substrate;Protein kinase C inhibitor;Small interfering ribonucleic acid;Inflammation;Signal pathway急性肺损伤(acute lung injury, ALI)是失控的系统性炎症反应综合征,肺微血管内皮细胞(pulmonary microvascular endothelial cells, PMVEC)为其主要效应细胞。炎症因子诱导PMVEC通透性增加是ALI发生的关键环节,而被脂多糖(lipopolysaccharide, LPS)激活的PMVEC也分泌多种炎症因子 ......
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