AG490对大鼠创伤性脑损伤急性期小胶质细胞激活的影响(4)
[17] Vilhardt F. Microglia： phagocyte and glia cell [J]. Int J Biochem Cell Biol，2005，37(1)：17-21.
[18] Davalos D，Grutzendler J，Yang G，et a1. ATP mediates rapid microglial response to local brain injury in vivo [J]. Nat Neurosci，2005，8(6)：752-758.
[19] Flugel A，Bradl M，Kreutzberq GW，et al. Transformation of donor-derived bone marrow precursors into host microglia during auto-immune CNS inflammation and during the retrogxade response to axotemy [J]. J Neurosci Res，2001，66(1)：74-82.
, 百拇医药
[20]李力仙，王天佑，钟震宇，等.大鼠颅脑创伤后肿瘤坏死因子α及脑水含量变化[J]. 中国急救医学，1999，19(6)：323-325.
[21] Block ML， Hong JS. Microglia and inflammation-mediated neuro degeneration： multiple triggers with a common mechanism [J]. Prog Neurobiol，2005，76(2)：77-98.
[22]Gao HM， Hong JS. Why neurodegenerative diseases are progressive： uncontrolled inflammation drives disease progression [J]. Trends Immunol，2008，29(8)：357-365.
[23]Liu GJ，Nagarajah R，Banati RB，et al. Glutamate induces directed chemotaxis of microglia [J]. Eur J Neurosci，2009，29(6)：1108-1118.
, 百拇医药
[24]Huang C，Ma R，Sun S，et al. JAK2- STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro [J]. J Neuroimmunol，2008，204(1/2)：118-125.
[25]Li L，Gao Y，Zhang LL，et al. Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki2 2 cells [J]. Cancer Biol Ther，2008，7(11)：1787-1792.
[26]Patel HC，Menon DK，Tebbs S，et al. Specialist neurocritical care and outcome from head injury [J]. Intensive Care Med，2002，28(5)：547-553.
, 百拇医药
[27]Bouzat P，Francony G，Thomas S，et al. Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative [J]. Crit Care Med，2011，39(9)：2099-2105.
[28]Beziaud T，Ru Chen X，Ei Shafey N，et al. Simvastatin in traumatic brain injury： effect on brain edema mechanisms [J]. Crit Care Med，2011，39(10)：2300-2307.
[29]Kenne E，Erlandsson A，Lindbom L，et al. Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice [J]. J Neuroinflammation，2012，9(1)：17.
, http://www.100md.com
(收稿日期：2012-10-20)
(本文编辑：郑辛甜)
DOI：10.3760/cma.j.issn.1671-0282.2013.03.010
基金项目：山东省自然科学基金(ZR2011HM008)
作者单位：261000 山东省潍坊，潍坊医学院(曹健锋)；潍坊医学院附属医院神经外科(季泰令、曾现伟、杨斌、李瑜、潘顺、张波)；潍坊医学院附属医院心内科(杜爱玲)；济宁市金乡县人民医院神经外科(张兴光)；
通信作者：杜爱玲，Email：jtl185@yahoo.com.cn
中华急诊医学杂志2013年3月第22卷第3期Chin J Emerg Med，March 2013，Vol.22，No.3
P272-P275
, 百拇医药(曹健锋 季泰令 杜爱玲 张兴光 曾现伟 杨斌 李瑜 潘顺 张波)
[18] Davalos D，Grutzendler J，Yang G，et a1. ATP mediates rapid microglial response to local brain injury in vivo [J]. Nat Neurosci，2005，8(6)：752-758.
[19] Flugel A，Bradl M，Kreutzberq GW，et al. Transformation of donor-derived bone marrow precursors into host microglia during auto-immune CNS inflammation and during the retrogxade response to axotemy [J]. J Neurosci Res，2001，66(1)：74-82.
, 百拇医药
[20]李力仙，王天佑，钟震宇，等.大鼠颅脑创伤后肿瘤坏死因子α及脑水含量变化[J]. 中国急救医学，1999，19(6)：323-325.
[21] Block ML， Hong JS. Microglia and inflammation-mediated neuro degeneration： multiple triggers with a common mechanism [J]. Prog Neurobiol，2005，76(2)：77-98.
[22]Gao HM， Hong JS. Why neurodegenerative diseases are progressive： uncontrolled inflammation drives disease progression [J]. Trends Immunol，2008，29(8)：357-365.
[23]Liu GJ，Nagarajah R，Banati RB，et al. Glutamate induces directed chemotaxis of microglia [J]. Eur J Neurosci，2009，29(6)：1108-1118.
, 百拇医药
[24]Huang C，Ma R，Sun S，et al. JAK2- STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro [J]. J Neuroimmunol，2008，204(1/2)：118-125.
[25]Li L，Gao Y，Zhang LL，et al. Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki2 2 cells [J]. Cancer Biol Ther，2008，7(11)：1787-1792.
[26]Patel HC，Menon DK，Tebbs S，et al. Specialist neurocritical care and outcome from head injury [J]. Intensive Care Med，2002，28(5)：547-553.
, 百拇医药
[27]Bouzat P，Francony G，Thomas S，et al. Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative [J]. Crit Care Med，2011，39(9)：2099-2105.
[28]Beziaud T，Ru Chen X，Ei Shafey N，et al. Simvastatin in traumatic brain injury： effect on brain edema mechanisms [J]. Crit Care Med，2011，39(10)：2300-2307.
[29]Kenne E，Erlandsson A，Lindbom L，et al. Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice [J]. J Neuroinflammation，2012，9(1)：17.
, http://www.100md.com
(收稿日期：2012-10-20)
(本文编辑：郑辛甜)
DOI：10.3760/cma.j.issn.1671-0282.2013.03.010
基金项目：山东省自然科学基金(ZR2011HM008)
作者单位：261000 山东省潍坊，潍坊医学院(曹健锋)；潍坊医学院附属医院神经外科(季泰令、曾现伟、杨斌、李瑜、潘顺、张波)；潍坊医学院附属医院心内科(杜爱玲)；济宁市金乡县人民医院神经外科(张兴光)；
通信作者：杜爱玲，Email：jtl185@yahoo.com.cn
中华急诊医学杂志2013年3月第22卷第3期Chin J Emerg Med，March 2013，Vol.22，No.3
P272-P275
, 百拇医药(曹健锋 季泰令 杜爱玲 张兴光 曾现伟 杨斌 李瑜 潘顺 张波)