脓毒症大鼠肺组织抑制因子—1表达变化(2)
【Key words】Tissue inhibitor of metalloproteinases-1; Sepsis; Lung tissue;Acute respiratory distress syndrome; Histological changes; Cecal ligation and puncture; Leucocyte; Rat脓毒症(sepsis)是指由感染引起的全身炎症反应综合征(systemic inflammation response syndrome,SIRS),失控的SIRS进一步则引发多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS),而肺往往是最早受累的器官,其典型的病理改变是渗出性炎症。Hoffman研究小组[1]发现基质金属蛋白酶-9(Matrix metalloproteinase-9)的内源性抑制因子-1(tissue inhibitor of metalloproteinases-1 ......
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