NF????????—κB信号通路在急性肾损伤小鼠细胞凋亡中的作用(4)
综上所述,NF-κB信号传导通路在AKI小鼠细胞凋亡中起促凋亡的作用,特异性阻断NF-κB信号传导通路可减轻肾脏细胞凋亡,改善肾功能。
参考文献
[1]Angus DC,Linde - Zwirble WT,Lidicker J,et al.Epidemiology of severe sepsis in the United States: analysis of incidence,outcome,and associated costs of care[J]. Crit Care Med,2001,29(7):1303-1310.
[2]Rana AP, Sathyanarayana P,Lieberthal W.Role of apoptosis of renal tubular cells in acute renal failure: therapeutic implications[J].Apoptosis,2001,6(1): 83-102.
, 百拇医药
[3]Wheeler AP,Bernard GR.Treating patients with severe sepsis[J].N Engl J Med,1999,340(3):207-214.
[4]Donnahoo KK, Meldrum DR, Shenkar R, et al.Early renal ischemia, with or without reperfusion, activates NF-κB and increases TNF-α bioactivity in the kidney[J]. Urology,2000,163(4):1328-1332.
[5]王学斌,杨兴易,赵良,等.心肺复苏后大鼠肾小管上皮细胞凋亡的实验研究[J].中华急诊医学杂志,2006,11(10):982-986.
, 百拇医药 [6]霍冬梅,廖蕴华,冯伟,等.大鼠肾脏缺血再灌注模型两种术式比较[J].广西医科大学学报,2008,25 (5):743-744.
[7]Li HG, Gu HY,Sun BG. Protective effects of pyrrolidine dithiocarbamate on myocardium apoptosis induced by adriamycin in rats[J].Intern J Cardiol,2007,114(2):159 -165.
[8]Vyacheslav Y,Melnikov SF, Britta SM, et al. Neutrophilindependent mechanisms of caspase-1 and IL-18-mediated ischemic acute tubular necrosis in mice[J]. J Clin Invest, 2002, 110(8): 1083-1091.
, 百拇医药
[9]Rana A, Sathyanarayana P,Lieberthal W.Role of apoptosis of renal tubular cells in acute renal failure: therapeutic implications[J].Apoptosis,2001,6(1): 83-102.
[10]Karin M, Lin A. NF-κB at the crossroads of life and death[J].Nat Immunol,2002,3(3): 221-227.
[11]Verzola D,Bertolotto MB, Villaggio B.Oxidative stress mediates spoptotic vhanges induced by hyperglycemia in human tubular kidney cell[J].J Am Soc Nephrol, 2004,15(1): 85-87.
, 百拇医药
[12]Peng YH, Scott F. Nuclear factor-κB mediates kupffer cell apoptosis through transcriptional activation of fas/fasL[J].J Surg Res,2006,130(1):58-65.
[13]Ross MJ,Martinka S,D'Agati VD.NF-κB regulates Fas-mediated apoptosis in HIV-associated nephropathy[J].J Am Soc Nephrol,2005,16(8): 2403-2411.
[14]李莎,张焰,彭生.异丙酚对急性肺损伤大鼠肺组织凋亡及NF-κB p65的影响[J].中华急诊医学杂志,2011,20(5):494-497.
, http://www.100md.com [15]吴晓燕,任江华.N-乙酰半胱氨酸对心力衰竭兔核因子NF-κB活化及心肌凋亡的干预作用[J].中华急诊医学杂志,2008,17(3):276-280.
[16]Viatour P,Bentires - Alj M,Chariot A ,et al. NF - kappa B2/ p100 induces Bcl - 2 expression[J]. Leukemia, 2003,17 (7):1349 - 1356.
[17]Takase O, Minto AWM,Puri TS.Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis[J].Kid Intern, 2008,73(5): 567-577.
, http://www.100md.com
(收稿日期:2012-11-17)
(本文编辑:何小军)
DOI:10.3760/cma.j.issn.1671-0282.2013.04.010
基金项目:青年科技人才启动项目(QYK09165)
作者单位:210008 南京,南京医科大学鼓楼临床医学院ICU
通信作者:顾勤,Email:icuguqin@yahoo.com.cn
P384-P389
, 百拇医药(俞隼 顾勤 刘宁 郭晓芳)
参考文献
[1]Angus DC,Linde - Zwirble WT,Lidicker J,et al.Epidemiology of severe sepsis in the United States: analysis of incidence,outcome,and associated costs of care[J]. Crit Care Med,2001,29(7):1303-1310.
[2]Rana AP, Sathyanarayana P,Lieberthal W.Role of apoptosis of renal tubular cells in acute renal failure: therapeutic implications[J].Apoptosis,2001,6(1): 83-102.
, 百拇医药
[3]Wheeler AP,Bernard GR.Treating patients with severe sepsis[J].N Engl J Med,1999,340(3):207-214.
[4]Donnahoo KK, Meldrum DR, Shenkar R, et al.Early renal ischemia, with or without reperfusion, activates NF-κB and increases TNF-α bioactivity in the kidney[J]. Urology,2000,163(4):1328-1332.
[5]王学斌,杨兴易,赵良,等.心肺复苏后大鼠肾小管上皮细胞凋亡的实验研究[J].中华急诊医学杂志,2006,11(10):982-986.
, 百拇医药 [6]霍冬梅,廖蕴华,冯伟,等.大鼠肾脏缺血再灌注模型两种术式比较[J].广西医科大学学报,2008,25 (5):743-744.
[7]Li HG, Gu HY,Sun BG. Protective effects of pyrrolidine dithiocarbamate on myocardium apoptosis induced by adriamycin in rats[J].Intern J Cardiol,2007,114(2):159 -165.
[8]Vyacheslav Y,Melnikov SF, Britta SM, et al. Neutrophilindependent mechanisms of caspase-1 and IL-18-mediated ischemic acute tubular necrosis in mice[J]. J Clin Invest, 2002, 110(8): 1083-1091.
, 百拇医药
[9]Rana A, Sathyanarayana P,Lieberthal W.Role of apoptosis of renal tubular cells in acute renal failure: therapeutic implications[J].Apoptosis,2001,6(1): 83-102.
[10]Karin M, Lin A. NF-κB at the crossroads of life and death[J].Nat Immunol,2002,3(3): 221-227.
[11]Verzola D,Bertolotto MB, Villaggio B.Oxidative stress mediates spoptotic vhanges induced by hyperglycemia in human tubular kidney cell[J].J Am Soc Nephrol, 2004,15(1): 85-87.
, 百拇医药
[12]Peng YH, Scott F. Nuclear factor-κB mediates kupffer cell apoptosis through transcriptional activation of fas/fasL[J].J Surg Res,2006,130(1):58-65.
[13]Ross MJ,Martinka S,D'Agati VD.NF-κB regulates Fas-mediated apoptosis in HIV-associated nephropathy[J].J Am Soc Nephrol,2005,16(8): 2403-2411.
[14]李莎,张焰,彭生.异丙酚对急性肺损伤大鼠肺组织凋亡及NF-κB p65的影响[J].中华急诊医学杂志,2011,20(5):494-497.
, http://www.100md.com [15]吴晓燕,任江华.N-乙酰半胱氨酸对心力衰竭兔核因子NF-κB活化及心肌凋亡的干预作用[J].中华急诊医学杂志,2008,17(3):276-280.
[16]Viatour P,Bentires - Alj M,Chariot A ,et al. NF - kappa B2/ p100 induces Bcl - 2 expression[J]. Leukemia, 2003,17 (7):1349 - 1356.
[17]Takase O, Minto AWM,Puri TS.Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis[J].Kid Intern, 2008,73(5): 567-577.
, http://www.100md.com
(收稿日期:2012-11-17)
(本文编辑:何小军)
DOI:10.3760/cma.j.issn.1671-0282.2013.04.010
基金项目:青年科技人才启动项目(QYK09165)
作者单位:210008 南京,南京医科大学鼓楼临床医学院ICU
通信作者:顾勤,Email:icuguqin@yahoo.com.cn
P384-P389
, 百拇医药(俞隼 顾勤 刘宁 郭晓芳)
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