【Key words】Sepsis；Volume responsiveness；Passive leg raising test；Early goal-directed therapy；Fluid resuscitation； Central venous oxygen saturation； Central venous-to-arterial carbon dioxide difference；Shock

    脓毒症是临床上古老而难治的临床综合征^[1]；以发病率高、费用昂贵、病死率高为其特点^[2-3]。所有严重脓毒症患者最初表现为低血压伴血乳酸水平≥4 mmol/L、仅低血压或仅血乳酸水平≥4 mmol/L，分别占16.6 %、49.5 % 和 5.4 % ；三组患者病死率分别高达46.1 %、36.7 %、30%^[4] ......