细胞因子和抑郁症(3)
虽然对于细胞因子和抑郁症之间的关系还存在很多不明确之处，然而，目前的假说已为与抑郁症相关的病理学和心理学机制研究创立了新的观点并为寻求发展新一代的抗抑郁药提供了方向。相信伴随着研究的不断深入和完善，细胞因子在抑郁症中的确切角色会逐渐明了。
参考文献
[1] Capuron L, Hauser P, Hinze-Selch D, et al. Treatment of cytokine-induction depression. Brain Behavior and Immune, 2002, 16(5): 575~580
[2] Kent S, Bluthé R M, Kelley K W, et al. Sickness behavior as a new target for drug development. Trends Pharmacology Science, 1992, 13: 24~28
, http://www.100md.com
[3] 祖蓓蓓. 抑郁症与免疫抑制.国外医学精神病分册，2004，31(2)：97~99
[4] Maes M. Evidence for an immune response in major depression: a review and hypothesis. Progress in Neuro-Psychopharmacology & Biological psychiatry, 1995, 19: 11~38
[5]Kronfol Z. Immune dysregulation in major depression: a critical review of existing evidence. Int. J. Nuropsychophamacol, 2002, 5: 333~343
[6] Suarez E C, Lewis J C, Krishnan R R, et al. Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. Psychoneuroendocrinology, 2004; 29(9): 1119~1128
, http://www.100md.com
[7] Levine J, Barak Y, Chengappa K N, et al. Cerebrospinal cytokine level in patients with acute depression. Neuropsycholibiology, 1999, 40: 171~176
[8] Olga J.G, Marieke C. W, Maes M, et al. Cytokines and major depression. Progress in Neuro-Psychopharmacology & Biological psychiatry, 2005, 29: 201~217
[9] Pollak Y, Ovadia H, Yirmiya R, et al. Behavior aspect of experimental autoimmune encephalomyelitis. J. Neuroimmunology, 2000, 104(1): 31~36
, 百拇医药
[10] Menzies H, Chochinov H M, Breitbart W, et al. Cytokines, cancer and depression: connecting the dots. J Support Oncol, 2005; 3(1): 55~57
[11] Constant A, Castera l, Dantzer R, et al. Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/ hypomanic and depressive symptoms. J Clin Psychiatry, 2005, 66(8): 1050~1057.
[12] 亓晓丽，林文娟. 焦虑和抑郁动物模型的研究方法和策略. 心理科学进展，2005，13(3)：327~332
, 百拇医药
[13] Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Research, 1996, 711: 163~174
[14] De La Garza R. Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as animal model of depression: focus on anhedonia. Neuroscience & biobehavioral Reviews, 2005, 29: 761~770
[15] Anisman H., Kokkinidis L., Merali Z. Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation. brain research, 1996, 731(1-2): 1~11
, 百拇医药
[16] Avitsur R， Yirmiya R. Cytokines inhibit sexual behavior in female rats: I. Synergistic effects of tumor necrosis factor alpha and interleukin-1.Brain, Behavior & Immune, 1999, 13(1): 14~32
[17] Marvel F A., Chen C C, Badr N, et al. Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain, Behavior, and Immunity, 2004, 18: 123~134
[18] Yirmiya R, Pollak Y, Barak O, et al. Effects of antidepressant drugs on the behavioral and physiological responses to LPS in redents. Neuropsychopharmacology, 2001, 24: 531~544
[ 上 页 ] [ 下 页 ], 百拇医药(潘玉芹 林文娟)
参考文献
[1] Capuron L, Hauser P, Hinze-Selch D, et al. Treatment of cytokine-induction depression. Brain Behavior and Immune, 2002, 16(5): 575~580
[2] Kent S, Bluthé R M, Kelley K W, et al. Sickness behavior as a new target for drug development. Trends Pharmacology Science, 1992, 13: 24~28
, http://www.100md.com
[3] 祖蓓蓓. 抑郁症与免疫抑制.国外医学精神病分册，2004，31(2)：97~99
[4] Maes M. Evidence for an immune response in major depression: a review and hypothesis. Progress in Neuro-Psychopharmacology & Biological psychiatry, 1995, 19: 11~38
[5]Kronfol Z. Immune dysregulation in major depression: a critical review of existing evidence. Int. J. Nuropsychophamacol, 2002, 5: 333~343
[6] Suarez E C, Lewis J C, Krishnan R R, et al. Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. Psychoneuroendocrinology, 2004; 29(9): 1119~1128
, http://www.100md.com
[7] Levine J, Barak Y, Chengappa K N, et al. Cerebrospinal cytokine level in patients with acute depression. Neuropsycholibiology, 1999, 40: 171~176
[8] Olga J.G, Marieke C. W, Maes M, et al. Cytokines and major depression. Progress in Neuro-Psychopharmacology & Biological psychiatry, 2005, 29: 201~217
[9] Pollak Y, Ovadia H, Yirmiya R, et al. Behavior aspect of experimental autoimmune encephalomyelitis. J. Neuroimmunology, 2000, 104(1): 31~36
, 百拇医药
[10] Menzies H, Chochinov H M, Breitbart W, et al. Cytokines, cancer and depression: connecting the dots. J Support Oncol, 2005; 3(1): 55~57
[11] Constant A, Castera l, Dantzer R, et al. Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/ hypomanic and depressive symptoms. J Clin Psychiatry, 2005, 66(8): 1050~1057.
[12] 亓晓丽，林文娟. 焦虑和抑郁动物模型的研究方法和策略. 心理科学进展，2005，13(3)：327~332
, 百拇医药
[13] Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Research, 1996, 711: 163~174
[14] De La Garza R. Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as animal model of depression: focus on anhedonia. Neuroscience & biobehavioral Reviews, 2005, 29: 761~770
[15] Anisman H., Kokkinidis L., Merali Z. Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation. brain research, 1996, 731(1-2): 1~11
, 百拇医药
[16] Avitsur R， Yirmiya R. Cytokines inhibit sexual behavior in female rats: I. Synergistic effects of tumor necrosis factor alpha and interleukin-1.Brain, Behavior & Immune, 1999, 13(1): 14~32
[17] Marvel F A., Chen C C, Badr N, et al. Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain, Behavior, and Immunity, 2004, 18: 123~134
[18] Yirmiya R, Pollak Y, Barak O, et al. Effects of antidepressant drugs on the behavioral and physiological responses to LPS in redents. Neuropsychopharmacology, 2001, 24: 531~544
[ 上 页 ] [ 下 页 ], 百拇医药(潘玉芹 林文娟)