92例伏立康唑治疗肺真菌感染患者的临床观察(2)
伏立康唑无论是作为一线用药还是二线用药,在治疗肺真菌感染上都有较好的疗效,并且可以通过血脑屏障,临床起效相对较快。对曲霉菌及其他霉菌具有较强杀灭作用,体外抗念珠菌活性是氟康唑的10-100倍,对克柔念珠菌等耐药念珠菌也有抗菌作用。我们的研究证实,伏立康唑是一种有效的、安全的广谱抗真菌药物,在抗肺真菌治疗中能够给患者带来获益。
参考文献
[1]Herbrecht R;Denning DW;Patterson TF,et al.Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. [J ]N Engl J Med.2002V347N6 :408-15
[2]Schwartz S;Ruhnke M ,et al.Poor efficacy of amphotericin B-based therapy in CNS aspergillosis. [J ] Mycoses.2007V50N3 :196-200
[3]Perfect JR;Marr KA,et al . Voriconazole treatment for less-common, emerging, or refractory fungal infections.
[4]Walsh TJ;Pappas P,et al. Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever.[J] N Engl J Med.2002V346N4 :225-34
[5]赵朴,薛阿利,冯爱梅,等.伏立康唑治疗恶性血液病患者合并侵袭性真菌感染临床疗效分析[J].中华医院感染学杂志,2012,22(22):5115-5117.
[6]Boyd AE;Modi S ,et al,Adverse reactions to voriconazole. [J] Clin InfectDis.2004V39N8 :1241-4, http://www.100md.com(吴连君 郭庆 赵昆)
参考文献
[1]Herbrecht R;Denning DW;Patterson TF,et al.Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. [J ]N Engl J Med.2002V347N6 :408-15
[2]Schwartz S;Ruhnke M ,et al.Poor efficacy of amphotericin B-based therapy in CNS aspergillosis. [J ] Mycoses.2007V50N3 :196-200
[3]Perfect JR;Marr KA,et al . Voriconazole treatment for less-common, emerging, or refractory fungal infections.
[4]Walsh TJ;Pappas P,et al. Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever.[J] N Engl J Med.2002V346N4 :225-34
[5]赵朴,薛阿利,冯爱梅,等.伏立康唑治疗恶性血液病患者合并侵袭性真菌感染临床疗效分析[J].中华医院感染学杂志,2012,22(22):5115-5117.
[6]Boyd AE;Modi S ,et al,Adverse reactions to voriconazole. [J] Clin InfectDis.2004V39N8 :1241-4, http://www.100md.com(吴连君 郭庆 赵昆)