外阴上皮内瘤变组织中P16和Ki-67的表达及其意义(3)
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本研究结果显示：P16和Ki-67在外阴上皮正常组织、低级别VIN与高级别VIN组织之间的阳性表达率具有显著性差异，可敏感地鉴别出高级别VIN；采用二者联合标记，更能有效地降低假阳性病例的干扰，提高VIN诊断的特异性。
[参考文献]
[1] HART W R. Vulvar intraepithelial neoplasia; historical aspects current status[J]. Int J Gynecol, 2001,20:16-30.
[2] MCNALLY O M, MULVANY N J. VIN Ⅲ: a clinicopathological review[J]. Int J Gynecol Cancer,2002,12:490-495.
[3] 史健，郑军生，尹方，等.宫颈上皮内瘤变P16、P53、Ki-67的表达与高危型HPV感染及其临床意义[J].南方医科大学学报，2007，27(1)：515-517.
[4] SARAH M B, ISAN E, DEBRA K, et al. Immunohistochemical Expression of P16 and Ki-67 correlates with degrdd of anal intraepithelial neoplasia[J]. Am J Surg Pathol, 2007,31(4):555-561.
[5] STANLEY J， ROBBO Y.女性生殖道病理学[M].回允中主译.北京：北京大学医学出版社，2005：41.
[6] GROSS G, HAGEDORN M, IKENBERG H. Bowenoid papulosis. Presence of human papillomavirus(HPV) structural antigens and of HPV 16-related DNA sequences[J]. Arch Dermatol, 1985，121:858-863.
[7] KLASES R, BENNER A, FRIENDRICH T, et al. P16 INK4 a immumohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia[J]. Am J Surg Pathol, 2002,26(11):1389-1399.
本研究结果显示：P16和Ki-67在外阴上皮正常组织、低级别VIN与高级别VIN组织之间的阳性表达率具有显著性差异，可敏感地鉴别出高级别VIN；采用二者联合标记，更能有效地降低假阳性病例的干扰，提高VIN诊断的特异性。
[参考文献]
[1] HART W R. Vulvar intraepithelial neoplasia; historical aspects current status[J]. Int J Gynecol, 2001,20:16-30.
[2] MCNALLY O M, MULVANY N J. VIN Ⅲ: a clinicopathological review[J]. Int J Gynecol Cancer,2002,12:490-495.
[3] 史健，郑军生，尹方，等.宫颈上皮内瘤变P16、P53、Ki-67的表达与高危型HPV感染及其临床意义[J].南方医科大学学报，2007，27(1)：515-517.
[4] SARAH M B, ISAN E, DEBRA K, et al. Immunohistochemical Expression of P16 and Ki-67 correlates with degrdd of anal intraepithelial neoplasia[J]. Am J Surg Pathol, 2007,31(4):555-561.
[5] STANLEY J， ROBBO Y.女性生殖道病理学[M].回允中主译.北京：北京大学医学出版社，2005：41.
[6] GROSS G, HAGEDORN M, IKENBERG H. Bowenoid papulosis. Presence of human papillomavirus(HPV) structural antigens and of HPV 16-related DNA sequences[J]. Arch Dermatol, 1985，121:858-863.
[7] KLASES R, BENNER A, FRIENDRICH T, et al. P16 INK4 a immumohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia[J]. Am J Surg Pathol, 2002,26(11):1389-1399.
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