125I粒子植入小鼠肝脏对肝纤维化血清指标的影响(1)
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[摘要] 目的:观察不同剂量125I粒子植入小鼠肝脏后对肝纤维化血清指标的影响。方法:50只昆明小鼠随机分为正常对照组(A组)和不同剂量125I粒子(125I粒子放射性活度依次为0、18.5、37.0和74.0 MBq)植入组(依次为B、C、D、E组)共5组(n10)，30 d处死，采用ELISA法测定血清Ⅲ型前胶原(PC Ⅲ)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)和层粘连蛋白(LN)浓度。结果:E组PC Ⅲ、Ⅳ-C、HA和LN测定结果依次为(57.96±11.22)、(30.69±9.86)、(170.96±49.21)和(75.58±13.47) ng·ml-1，与A组比较P<0.05，其他各组的测定结果无明显统计学差异。结论:小鼠肝脏植入125I粒子放射性活度≤37 MBq时，对肝纤维化指标无明显影响，125I粒子放射性活度达74 MBq时会引发各项肝纤维化指标的升高。
[关键词] 125I粒子； 小鼠； 肝纤维化
[中图分类号] R730.55; R-33 [文献标识码] A [文章编号] 1671-7562(2011)01-0035-03
doi:10.3969/j.issn.1671-7562.2011.01.010
[收稿日期] 2010-10-25 [修回日期] 2010-11-11
[作者简介] 黄唯(1982-)，女，湖北孝感人，技师。E-mail: 185023313@qq.com
Effect of liver fibrosis on serum markers after 125I seed
implanted into mouse liver
HUANG Wei
(Department of Nuclear Medicine, Xiaogan Central Hospital, Xiaogan 432100, China)
[Abstract] Objective: To observed the effect of liver fibrosis on serum markers after 125I seed implanted into mouse liver of different doses. Methods: 50 mice were randomly divided into control and 4 experimental groups of different doses of particles in(n10). 125I particle radioactivity order of 0, 18.5, 37.0 and 74.0 MBq, mice were sacrificed on day 30.Serum type Ⅲ procollagen(PC Ⅲ), Ⅳ collagen(Ⅳ-C), hyaluronic acid(HA) and laminin(LN) were detected by ELISA. Results: Serum type Ⅲ procollagen(PC Ⅲ), Ⅳ collagen(Ⅳ-C), hyaluronic acid(HA) and laminin(LN) in group E were respectively(57.96±11.22), (30.69±9.86), (170.96±49.21) and (75.58±13.47) ng·ml-1, significantly different from that in the control group P<0.05, but not from those in other experimental groups. Conclusions： A dose equal to or less than 37 MBq imposes no significant effect on liver fibrosis, however 74 MBq will increase the values of the indicators for fibrosis.
[Key words] 125 I seed； mice； liver fibrosis
放射性125I粒子组织间植入已经在多种肿瘤的治疗中显示了有效的肿瘤局部控制率。在国外，放射性粒子植入治疗已成为早期前列腺癌的首选治疗方法；在国内，放射性粒子植入对恶性实体瘤的临床应用也较为广泛 ......
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