早期瑞舒伐他汀干预对不稳定型心绞痛支架术后血清妊娠相关蛋白A和高敏C反应蛋白的影响(1)
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摘要：目的 探讨瑞舒伐他汀对血脂水平正常的不稳定型心绞痛患者行PCI术后妊娠相关蛋白A(PAPP-A)及高敏C反应蛋白(hs-CRP)的影响。方法 56例血脂水平正常的不稳定型心绞痛患者，随机分为瑞舒伐他汀组和常规治疗组，两组患者分别于PCI术前、术后24 h、术后1个月检测血清PAPP-A 和hs-CRP水平。结果 两组患者术后24 h与术前比较，血清PAPP-A和hs-CRP浓度均有明显升高，但两组间比较，无明显差异；术后1个月，两组血清PAPP-A 和hs-CRP水平与术后24 h比较，均有回降，但瑞舒伐他汀组较常规治疗组回降更为明显，两者存在统计学意义(P<0.05)。结论 早期使用瑞舒伐他汀能更有效降低不稳定型心绞痛患者PCI术后PAPP-A和hs-CRP水平。
关键词:瑞舒伐他汀;不稳定型心绞痛；妊娠相关蛋白A；高敏C反应蛋白；经皮冠脉介入治疗
中图分类号：R541.4 R256.2 文献标识码：B 文章编号：1672-1349(2011)07-0781-03
Influence of Rosuvastatain on Plasma PAPP-A and hs-CRP after PCI in Unstable Angina Pectoris
Weng Jianxin，Liu Qiang，Zou Huihua，et al
Sun Yatsen Cardiovascular Hospital，Shenzhen(Shenzhen 518102)
Abstract:Objective To investigate the effects of rosuvastatain on the pregnancy-associated plasma protein-A(PAPP-A) and high sensitivity C-reactive protein(hs-CRP) afterpercutaneous coronary intervention(PCI) in patients(pts) with unstable angina pectoris(UAP).Methods Fifty-six pts with UAP were randomly divided into two groups：Rosuvastatain group(n30) treated with rosuvastatain and control group(n26) treated with routine treatment.The levels of PAPP-A and hs-CRP were detected before PCI and at 24 hours，1 month after PCI.ResultsThe levels of PAPP-A and hs-CRP were increased at the 24 hours after PCI in two groups(P<0.05).The levels of PAPP-A and hs-CRP were decreased at 1 month after PCI in two groups(P<0.05).The levels of PAPP-A and hs-CRP were obviously lower than that in control group(P<0.05).Conclusion Rosuvastatain could decrease the level of PAPP-A and hs-CRP significantly in pts with UAP after PCI.
Key words：Rosuvastatain；unstable angina pectoris；pregnancy-associated plasma protein-A；high sensitivity C-reactive protein；percutaneous coronary intervention
不稳定型心绞痛(UAP)是一种严重的心血管疾病 ......
摘要：目的 探讨瑞舒伐他汀对血脂水平正常的不稳定型心绞痛患者行PCI术后妊娠相关蛋白A(PAPP-A)及高敏C反应蛋白(hs-CRP)的影响。方法 56例血脂水平正常的不稳定型心绞痛患者，随机分为瑞舒伐他汀组和常规治疗组，两组患者分别于PCI术前、术后24 h、术后1个月检测血清PAPP-A 和hs-CRP水平。结果 两组患者术后24 h与术前比较，血清PAPP-A和hs-CRP浓度均有明显升高，但两组间比较，无明显差异；术后1个月，两组血清PAPP-A 和hs-CRP水平与术后24 h比较，均有回降，但瑞舒伐他汀组较常规治疗组回降更为明显，两者存在统计学意义(P<0.05)。结论 早期使用瑞舒伐他汀能更有效降低不稳定型心绞痛患者PCI术后PAPP-A和hs-CRP水平。
关键词:瑞舒伐他汀;不稳定型心绞痛；妊娠相关蛋白A；高敏C反应蛋白；经皮冠脉介入治疗
中图分类号：R541.4 R256.2 文献标识码：B 文章编号：1672-1349(2011)07-0781-03
Influence of Rosuvastatain on Plasma PAPP-A and hs-CRP after PCI in Unstable Angina Pectoris
Weng Jianxin，Liu Qiang，Zou Huihua，et al
Sun Yatsen Cardiovascular Hospital，Shenzhen(Shenzhen 518102)
Abstract:Objective To investigate the effects of rosuvastatain on the pregnancy-associated plasma protein-A(PAPP-A) and high sensitivity C-reactive protein(hs-CRP) afterpercutaneous coronary intervention(PCI) in patients(pts) with unstable angina pectoris(UAP).Methods Fifty-six pts with UAP were randomly divided into two groups：Rosuvastatain group(n30) treated with rosuvastatain and control group(n26) treated with routine treatment.The levels of PAPP-A and hs-CRP were detected before PCI and at 24 hours，1 month after PCI.ResultsThe levels of PAPP-A and hs-CRP were increased at the 24 hours after PCI in two groups(P<0.05).The levels of PAPP-A and hs-CRP were decreased at 1 month after PCI in two groups(P<0.05).The levels of PAPP-A and hs-CRP were obviously lower than that in control group(P<0.05).Conclusion Rosuvastatain could decrease the level of PAPP-A and hs-CRP significantly in pts with UAP after PCI.
Key words：Rosuvastatain；unstable angina pectoris；pregnancy-associated plasma protein-A；high sensitivity C-reactive protein；percutaneous coronary intervention
不稳定型心绞痛(UAP)是一种严重的心血管疾病 ......
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