血脂康对db/db糖尿病小鼠坐骨神经传导速度影响的研究(1)
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摘要：目的 探讨血脂康对db/db糖尿病小鼠坐骨神经传导速度的影响。方法 将12周龄db/db小鼠随机分为3组，分别给予血脂康低剂量(0.3 g/kg)、高剂量(0.6 g/kg)及安慰剂灌胃8周，同周龄db/m小鼠作为非糖尿病对照组。投药8周后行糖耐量试验，治疗前后分别测定db/db糖尿病小鼠及db/m小鼠坐骨神经的传导速度。结果 与db/db对照组比较，血脂康不同剂量组治疗8周后总胆固醇(TC)、低密度脂蛋白(LDL-C)、三酰甘油(TG)及空腹血糖下降(P<0.05)。糖负荷120 min后葡萄糖曲线下面积(AUCg)和胰岛素曲线下面积(AUCins)均低于db/db对照组，而血脂康两组之间比较无统计学意义。血脂康两组治疗后坐骨神经传导速度明显高于对照组，而高剂量组优于低剂量组。结论 血脂康在降低血脂、血糖的同时，能提高坐骨神经传导速度，对周围神经具有保护作用，其作用独立于调脂降糖。
关键词：血脂康；2型糖尿病；坐骨神经传导速度
中图分类号：R745 R285.5 文献标识码：A 文章编号：1672-1349(2011)07-0842-03
Effects of Xuezhikang Capsule on Conduction Velocity of Sciatic Nerve in db/db Mice
Chen Maowei，Gu Ping，Ma Jian，et al
Department of Neurology，Nanjing General Hospital，Nanjing Military Command(Nanjing 210002)
Abstract:Objective To investigate the effect of Xuezhikang capsule(XZK) on motor nerve conduction velocity(MNCV) of sciatic nerve.Methods Mice models with diabetes were randomized to XZK low dose group(0.3 mg/kg)，XZK high dose group(0.6 g/kg) and control group(placebo).The age-matched nondiabetic littermates db/m mice were treated with placebo as the controls.After treatment for 8 weeks，intraperitoneal glucose tolerance test and insulin release test were performed.Motor nerve conduction velocity of sciatic nerve was determined.ResultsCompared withcontrol group，the levels of plasma total cholesterol,low density lipoprotein-cholesterol，triglyceride，fasting plasma glucose ......
摘要：目的 探讨血脂康对db/db糖尿病小鼠坐骨神经传导速度的影响。方法 将12周龄db/db小鼠随机分为3组，分别给予血脂康低剂量(0.3 g/kg)、高剂量(0.6 g/kg)及安慰剂灌胃8周，同周龄db/m小鼠作为非糖尿病对照组。投药8周后行糖耐量试验，治疗前后分别测定db/db糖尿病小鼠及db/m小鼠坐骨神经的传导速度。结果 与db/db对照组比较，血脂康不同剂量组治疗8周后总胆固醇(TC)、低密度脂蛋白(LDL-C)、三酰甘油(TG)及空腹血糖下降(P<0.05)。糖负荷120 min后葡萄糖曲线下面积(AUCg)和胰岛素曲线下面积(AUCins)均低于db/db对照组，而血脂康两组之间比较无统计学意义。血脂康两组治疗后坐骨神经传导速度明显高于对照组，而高剂量组优于低剂量组。结论 血脂康在降低血脂、血糖的同时，能提高坐骨神经传导速度，对周围神经具有保护作用，其作用独立于调脂降糖。
关键词：血脂康；2型糖尿病；坐骨神经传导速度
中图分类号：R745 R285.5 文献标识码：A 文章编号：1672-1349(2011)07-0842-03
Effects of Xuezhikang Capsule on Conduction Velocity of Sciatic Nerve in db/db Mice
Chen Maowei，Gu Ping，Ma Jian，et al
Department of Neurology，Nanjing General Hospital，Nanjing Military Command(Nanjing 210002)
Abstract:Objective To investigate the effect of Xuezhikang capsule(XZK) on motor nerve conduction velocity(MNCV) of sciatic nerve.Methods Mice models with diabetes were randomized to XZK low dose group(0.3 mg/kg)，XZK high dose group(0.6 g/kg) and control group(placebo).The age-matched nondiabetic littermates db/m mice were treated with placebo as the controls.After treatment for 8 weeks，intraperitoneal glucose tolerance test and insulin release test were performed.Motor nerve conduction velocity of sciatic nerve was determined.ResultsCompared withcontrol group，the levels of plasma total cholesterol,low density lipoprotein-cholesterol，triglyceride，fasting plasma glucose ......
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